Evidence map›Paper›PMID 34292442›Full record

ArticleBulletin of experimental biology and medicine2021

Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect.

A M Burdennyy, E A Filippova, N A Ivanova, S S Lukina, I V Pronina, V I Loginov, M V Fridman, T P Kazubskaya, D O Utkin, E A Braga and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Roles of enhancer RNAs in sex hormone-dependent cancers.Journal of cancer research and clinical oncology · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

A M BurdennyyResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
E A FilippovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
N A IvanovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
S S LukinaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
I V ProninaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
V I LoginovResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
M V FridmanN. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
T P KazubskayaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
D O UtkinN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
E A BragaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia. eleonora10_45@mail.ru.
N E KushlinskiiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUMinistry of Health of the Russian Federation · RUVavilov Institute of General Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metastasis of ovarian cancer. A multiple and significant (p<0.001) increase in methylation of a group of lncRNA genes (MEG3, SEMA3B-AS1, ZNF667-AS1, and TINCR) was shown by quantitative methylation-specific PCR using the non-parametric Mann-Whitney test. Moreover, methylation of SEMA3B-AS1, ZNF667-AS1, and TINCR genes in ovarian cancer tumors was detected for the first time. Comparative analysis of 19 samples of peritoneal metastases and paired primary tumors showed a significant decrease in the methylation level of the same 4 genes: MEG3 (p=0.004), SEMA3B-AS1 (p=0.002), TINCR (p=0.002), and ZNF667-AS1 (p<0.001). Reduced methylation of suppressor lncRNA genes in peritoneal metastases is probably associated with the involvement of these lncRNA in the regulation of plastic reversion of the epithelial-mesenchymal transition to the mesenchymal-epithelial transition. Thus, the effect of lncRNA and their methylation on the development of tumors and metastases of ovarian cancer was demonstrated, which is important for understanding of the pathogenesis and mechanisms of metastasis of ovarian cancer. New properties of lncRNA can find application in the development of new approaches in the therapy of ovarian cancer.

Indexed as

Carcinoma, EndometrioidCystadenocarcinoma, SerousDNA MethylationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMembrane GlycoproteinsNeoplasm GradingNeoplasm StagingOvarian NeoplasmsPeritoneal NeoplasmsRNA, Long NoncodingSemaphorinsGAS5 long non-coding RNA, humanMEG3 non-coding RNA, humanMembrane GlycoproteinsMORT long noncoding RNA, humanRNA, Long NoncodingSEMA3B protein, humanSemaphorinsTINCR lncRNA, humangenes SEMA3B-AS1, TINCR, and ZNF667-AS1long non-coding RNAmetastasesmethylationovarian cancer

Identifiers

PMID34292442
OpenAlexW3185558903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.