Evidence map›Paper›PMID 34292440›Full record

ArticleCancer causes & control : CCC2021

Theory, methods, and operational results of the Young Women's Health History Study: a study of young-onset breast cancer incidence in Black and White women.

Ellen M Velie, Lydia R Marcus, Dorothy R Pathak, Ann S Hamilton, Ralph DiGaetano, Ron Klinger, Bibi Gollapudi, Richard Houang, Nicole Carnegie, L Karl Olson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Adiposity throughout Adulthood and Risk of Young-Onset Breast Cancer Tumor Subtypes in the Young Women's Health History Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ellen M VelieZilber School of Public Health, University of WI - Milwaukee, 1240 N. 10th Street, Milwaukee, WI, 53201, USA. velie@uwm.edu.ORCID http://orcid.org/0000-0001-6865-9715
Lydia R MarcusZilber School of Public Health, University of WI - Milwaukee, 1240 N. 10th Street, Milwaukee, WI, 53201, USA.ORCID http://orcid.org/0000-0003-3748-5921
Dorothy R PathakDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road Room B601, East Lansing, MI, 48824, USA.ORCID http://orcid.org/0000-0002-5318-3985
Ann S HamiltonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 2001 N. Soto St, Los Angeles, CA, 90089-9239, USA.
Ralph DiGaetanoWestat Inc., 1650 Research Blvd, Rockville, MD, 20850, USA.
Ron KlingerWestat Inc., 1650 Research Blvd, Rockville, MD, 20850, USA.
Bibi GollapudiWestat Inc., 1650 Research Blvd, Rockville, MD, 20850, USA.
Richard HouangDepartment of Education, Michigan State University, 620 Farm Ln, East Lancing, MI, 48824, USA.
Nicole CarnegieDepartment of Mathematics, Montana State University, 732 Grant St, Bozeman, MT, 59717, USA.
L Karl OlsonDepartment of Physiology, Michigan State University, 567 Wilson Rd, East Lansing, MI, 48824, USA.
Amani AllenDepartments of Community Health Sciences and Epidemiology, School of Public Health, University of California Berkeley, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Zhenzhen ZhangDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Mail Code: KCRB-PROS, Portland, OR, 97239, USA.
Denise ModjeskDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 2001 N. Soto St, Los Angeles, CA, 90089-9239, USA.
Gwendolyn NormanCollege of Liberal Arts and Sciences, Wayne State University, 4841 Cass Avenue, Detroit, MI, 48201, USA.
Darek R LucasZilber School of Public Health, University of WI - Milwaukee, 1240 N. 10th Street, Milwaukee, WI, 53201, USA.
Sapna GuptaCancer Research Informatics Core, University of Southern California Norris Cancer Center, NRT LG507, 1450 Biggy St, Los Angeles, CA, 90033, USA.
Hallgeir RuiDepartment of Pathology, Medical College of Wisconsin, 8701 Watertown Plank RD., Milwaukee, WI, 53226, USA.
Kendra SchwartzDepartment of Family Medicine and Public Health Sciences, Wayne State University, 3939 Woodward Ave, Detroit, MI, 48201, USA.

Funding

Life Course Energy Balance and Breast Cancer Risk in Black/White Women Under 50R01CA136861 · NCI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI VELIE, ELLEN M · 2010 to 2015
$12.4M
Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
NCI NIH HHS R01 CA136861NCI NIH HHS R01CA136861NICHD NIH HHS K12 HD043488Office of Research on Women's Health K12HD043488
6 · The paper itself

Abstract

purposeThe etiology of young-onset breast cancer (BC) is poorly understood, despite its greater likelihood of being hormone receptor-negative with a worse prognosis and persistent racial and socioeconomic inequities. We conducted a population-based case-control study of BC among young Black and White women and here discuss the theory that informed our study, exposures collected, study methods, and operational results.

methodsCases were non-Hispanic Black (NHB) and White (NHW) women age 20-49 years with invasive BC in metropolitan Detroit and Los Angeles County SEER registries 2010-2015. Controls were identified through area-based sampling from the U.S. census and frequency matched to cases on study site, race, and age. An eco-social theory of health informed life-course exposures collected from in-person interviews, including socioeconomic, reproductive, and energy balance factors. Measured anthropometry, blood (or saliva), and among cases SEER tumor characteristics and tumor tissue (from a subset of cases) were also collected.

resultsOf 5,309 identified potentially eligible cases, 2,720 sampled participants were screened and 1,812 completed interviews (682 NHB, 1140 NHW; response rate (RR): 60%). Of 24,612 sampled control households 18,612 were rostered, 2,716 participants were sampled and screened, and 1,381 completed interviews (665 NHB, 716 NHW; RR: 53%). Ninety-nine% of participants completed the main interview, 82% provided blood or saliva (75% blood only), and SEER tumor characteristics (including ER, PR and HER2 status) were obtained from 96% of cases.

conclusionsResults from the successfully established YWHHS should expand our understanding of young-onset BC etiology overall and by tumor type and identify sources of racial and socioeconomic inequities in BC.

Indexed as

Breast NeoplasmsAdultBlack or African AmericanCase-Control StudiesFemaleHumansIncidenceMiddle AgedWhite PeopleYoung AdultBreast cancerEpidemiologyHealth status disparitiesLife-coursePremenopauseYoung-onset breast cancer

Identifiers

PMID34292440
PMCPMC8416838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.