Evidence map›Paper›PMID 34292379›Full record

ArticlePediatric nephrology (Berlin, Germany)2022

De novo lupus-like glomerulonephritis after pediatric non-kidney organ transplantation.

Cristina M Farkas-Skiles, Robert B Ettenger, Jonathan E Zuckerman, Meghan Pearl, Robert S Venick, Patricia L Weng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cristina M Farkas-SkilesDepartment of Pediatrics, Division of Nephrology, University of California Los Angeles Medical Center, Los Angeles, CA, USA. farkas.cristina@gmail.com.ORCID http://orcid.org/0000-0003-0912-626X
Robert B EttengerDepartment of Pediatrics, Division of Nephrology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Jonathan E ZuckermanDepartment of Pathology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Meghan PearlDepartment of Pediatrics, Division of Nephrology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Robert S VenickDepartment of Pediatrics, Division of Gastroenterology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Patricia L WengDepartment of Pediatrics, Division of Nephrology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe propose a novel clinically significant finding, de novo lupus-like glomerulonephritis (DNLLGN), in patients with autoantibodies and kidney abnormalities in pediatric liver transplant (LT) and intestinal inclusive transplants (ITx).

methodsWe describe the clinical, serologic, and histopathologic presentation and kidney outcomes in eight patients from our center found to have DNLLGN on kidney biopsy.

resultsPediatric recipients of non-kidney solid organ transplants developed an unusual de novo immune complex glomerulonephritis with morphologic similarity to lupus nephritis. Six had isolated LT (0.9% of all pediatric LT at our center) and two had ITx (2.1% of all ITx). Five (63%) presented with nephrotic syndrome. Five patients had autoantibodies. Patients underwent kidney biopsy at a mean of 11.5 years in LT and 2.8 years in ITx after the index transplant. Biopsies demonstrated changes similar to focal or diffuse active lupus. Follow-up eGFR at a mean of 6 years after biopsy showed a mean decrease of 30 ml/min/1.73 m

conclusionsDNLLGN has not been previously recognized in this clinical setting, yet 8 kidney biopsies from pediatric recipients of LT and ITx at our center in 25 years demonstrated this finding. DNLLGN appears to be an under-reported phenomenon of clinical significance. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

GlomerulonephritisLupus NephritisOrgan TransplantationAutoantibodiesChildHumansLiver TransplantationAutoantibodiesGlomerulonephritisIntestinal transplantLiver transplantPediatric

Identifiers

PMID34292379
PMCPMC8674157
OpenAlexW3186468691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.