ArticleeLife2021
Molecular characterization of projection neuron subtypes in the mouse olfactory bulb.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- A topographical organization in the primary olfactory cortex.Nature communications · 2026Article
- Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR-Dependent Translational Control of Synaptic Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative GWAS using global and Indian Reference Panels reveals non-coding drivers of COVID-19 severity and mortality.PLoS neglected tropical diseases · 2026Article
- S3RL: Enhancing Spatial Single-Cell Transcriptomics With Separable Representation Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Signal-based spatial domain identification of spatially resolved transcriptomics with multigraph fusion.Briefings in bioinformatics · 2026Article
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.Journal of cell science · 2025Article
- Article
- The neurexin gene family regulates olfactory glomerular formation.Cell reports · 2025Article
- Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution.Nature neuroscience · 2025Article
- Robust Spatial Cell-Type Deconvolution with Qualitative Reference for Spatial Transcriptomics.Small methods · 2025Article
- 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.Journal of neuroinflammation · 2025Article
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Intranasal iron administration induces iron deposition, immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice.Zoological research · 2025Article
- Brain Regulates Neuronal Activity Directly through the Heartbeat: A New Pathway of Heart-Brain Interaction.Aging and disease · 2024Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive input from the nose and project to diverse cortical and subcortical areas. Morphological and physiological studies have highlighted functional heterogeneity, yet no molecular markers have been described that delineate PN subtypes. Here, we used viral injections into olfactory cortex and fluorescent nucleus sorting to enrich PNs for high-throughput single nucleus and bulk RNA deep sequencing. Transcriptome analysis and RNA in situ hybridization identified distinct mitral and tufted cell populations with characteristic transcription factor network topology, cell adhesion, and excitability-related gene expression. Finally, we describe a new computational approach for integrating bulk and snRNA-seq data and provide evidence that different mitral cell populations preferentially project to different target regions. Together, we have identified potential molecular and gene regulatory mechanisms underlying PN diversity and provide new molecular entry points into studying the diverse functional roles of mitral and tufted cell subtypes.
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