ArticleNeuropsychology2021
The latent factor structure underlying regional brain volume change and its relation to cognitive change in older adults.
Article in Neuropsychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Domain-specific changes in everyday cognition: Associations with diagnosis change and gray matter volume change.Neuropsychology · 2026Article
- The longitudinal effects of global and regional brain measurements on cognitive abilities.Scientific reports · 2025Article
- The effects of CNS atrophy and ICVD on tests of executive function and functional status are mediated by intelligence.Cerebral circulation - cognition and behavior · 2023Article
- Episodic Memory and Executive Function Are Differentially Affected by Retests but Similarly Affected by Age in a Longitudinal Study of Normally-Aging Older Adults.Frontiers in aging neuroscience · 2022Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveLate-life changes in cognition and brain integrity are both highly multivariate, time-dependent processes that are essential for understanding cognitive aging and neurodegenerative disease outcomes. The present study seeks to identify a latent variable model capable of efficiently reducing a multitude of structural brain change magnetic resonance imaging (MRI) measurements into a smaller number of dimensions. We further seek to demonstrate the validity of this model by evaluating its ability to reproduce patterns of coordinated brain volume change and to explain the rate of cognitive decline over time.
methodWe used longitudinal cognitive data and structural MRI scans, obtained from a diverse sample of 358 participants (
resultsResults supported a bifactor model for brain change with four group factors (prefrontal, temporolimbic, medial temporal, and posterior association) and one general change factor (global atrophy). Atrophy in the global (β = 0.434,
conclusionsThe current results suggest that brain change across 27 bilateral regions of interest can be grouped into five change factors, three of which (global gray matter, temporolimbic, and medial temporal lobe atrophy) are strongly associated with cognitive decline. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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