ArticleOrganic letters2021
Cascade aza-Wittig/6π-Electrocyclization in the Synthesis of 1,6-Dihydropyridines.
Article in Organic letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Generation of Mono- and BisazabicyclicOrganic letters · 2026Article
- One-pot reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate: an efficient approach to highly functionalized 1,6-dihydropyridine derivatives.RSC advances · 2025Article
- New efficient synthesis of polysubstituted 3,4-dihydroquinazolines and 4Beilstein journal of organic chemistry · 2022Article
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Authors and funding
4 authors.
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Abstract
A metal-free protocol for the synthesis of substituted 1,6-dihydropyridines with quaternary stereogenic centers via a cascade aza-Wittig/6π-electrocyclization process has been developed. The high functional group compatibility and broad scope of this method were demonstrated by using a wide range of easily available vinyliminophosphoranes and ketones, with yields up to 97%. A modification of the obtained products allowed for an increase in complexity and chemical diversity. Finally, attempts for asymmetric synthesis of 1,6-dihydropyridines are demonstrated.
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