Evidence map›Paper›PMID 34291686›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2021

Effects of Mild and Moderate Monoclonal Antibody Dose on Inflammation, Bone Loss, and Activation of the Central Nervous System in a Female Collagen Antibody-induced Arthritis Mouse Model.

Bonnie Williams, Florence Lees, Helen Tsangari, Mark R Hutchinson, Egon Perilli, Tania N Crotti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bonnie WilliamsAdelaide Medical School.
Florence LeesAdelaide Medical School.
Helen TsangariAdelaide Medical School.
Mark R HutchinsonAdelaide Medical School.
Egon PerilliThe University of Adelaide, Adelaide, SA, Australia, and Medical Device Research Institute, College of Science and Engineering, Flinders University, Adelaide, SA, Australia.
Tania N CrottiAdelaide Medical School.
University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induction of severe inflammatory arthritis in the collagen antibody-induced arthritis (CAIA) murine model causes extensive joint damage and pain-like behavior compromising analysis. While mild models are less severe, their reduced, variable penetrance makes assessment of treatment efficacy difficult. This study aimed to compare macroscopic and microscopic changes in the paws, along with central nervous system activation between a mild and moderate CAIA model. Balb/c mice (

Indexed as

Disease Models, AnimalAnimalsAntibodies, MonoclonalArthritis, ExperimentalArthritis, RheumatoidBone ResorptionCartilage, ArticularEdemaFemaleForelimbHistocytochemistryLipopolysaccharidesMiceMice, Inbred BALB CNeurogliaOsteoclastsAntibodies, MonoclonalLipopolysaccharidesboneglial cellsinflammationinflammatory arthritismicro-computed tomographyosteoclast

Identifiers

PMID34291686
PMCPMC8335846
OpenAlexW3184634828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.