ArticleNeuropsychopharmacology reports2021
Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults.
Article in Neuropsychopharmacology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- HFE genotype influences substantia nigra iron accumulation and Parkinson's disease progression.medRxiv : the preprint server for health sciences · 2026Article
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes.Molecular biology and evolution · 2024Article
- HFE Mutations in Neurodegenerative Disease as a Model of Hormesis.International journal of molecular sciences · 2024Review
- Automated segmentation of midbrain nuclei using deep learning and multisequence MRI: A longitudinal study on iron accumulation with age.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Review
- Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study.International journal of molecular sciences · 2023Article
- Quantifying Brain Iron in Hereditary Hemochromatosis Using R2* and Susceptibility Mapping.AJNR. American journal of neuroradiology · 2022Article
- Role of Iron in Aging Related Diseases.Antioxidants (Basel, Switzerland) · 2022Article
- A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression.Biomedicines · 2022Review
- The (Bio)Chemistry of Non-Transferrin-Bound Iron.Molecules (Basel, Switzerland) · 2022Review
- Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory.Frontiers in human neuroscience · 2022Article
- Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults.Neuropsychopharmacology reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain iron overload is linked to brain deterioration, and cognitive and motor impairment in neurodegenerative disorders and normal aging. Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral iron overload. However, links to brain iron load and cognition are less consistent and data are scarce. AIMS AND
methodsUsing quantitative susceptibility mapping with magnetic resonance imaging, we investigated whether C282Y and H63D contributed to aging-related increases in brain iron load and lower cognitive and motor performance in 208 healthy individuals aged 20-79 years. We also assessed the modulatory effects of HFE mutations on associations between performance and brain iron load, as well as peripheral iron metabolism.
resultsIndependent of age, carriers of either C282Y and/or H63D (HFE-pos group, n = 66) showed a higher load of iron in putamen than non-carriers (HFE-neg group, n = 142), as well as higher transferrin saturation and lower transferrin and transferrin receptors in blood. In the HFE-neg group, higher putaminal iron was associated with lower working memory. In the HFE-pos group, higher putaminal iron was instead linked to higher executive function, and lower plasma transferrin was related to higher episodic memory. Iron-performance associations were modest albeit reliable.
conclusionOur findings suggest that HFE status is characterized by higher regional brain iron load across adulthood, and support the presence of a modulatory effect of HFE status on the relationships between iron load and cognition. Future studies in healthy individuals are needed to confirm the reported patterns.
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