ArticleBrain and behavior2021
Non-motor phenotypic subgroups in adult-onset idiopathic, isolated, focal cervical dystonia.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Improving Measurement and Priorities for Assessment in Clinical Trials of childhood-onset Dystonia International Core Outcome Set (Dystonia IMPACT-COS): A protocol.NIHR open research · 2026Article
- Polysomnographic characteristics in patients with idiopathic dystonia.Clinical parkinsonism & related disorders · 2026Article
- External Factors Modulating Pain and Pain-Related Functional Impairment in Cervical Dystonia.Movement disorders clinical practice · 2024Article
- Prevalence and temporal relationship of clinical co-morbidities in idiopathic dystonia: a UK linkage-based study.Journal of neurology · 2024Article
- Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1.Arquivos de neuro-psiquiatria · 2024Review
- Are Cognitive Symptoms Part of the Phenotypic Spectrum of Idiopathic Adult-Onset Dystonia? Summary of Evidence from Controlled Studies.Movement disorders clinical practice · 2024Review
- [Pain and cervical dystonia].Schmerz (Berlin, Germany) · 2024Review
- Non-Motor Symptoms and Quality of Life in Patients with PRRT2-Related Paroxysmal Kinesigenic Dyskinesia.Movement disorders clinical practice · 2023Article
- Article
- Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia.Journal of neurology · 2023Article
- Clinical and genotypic analysis in determining dystonia non-motor phenotypic heterogeneity: a UK Biobank study.Journal of neurology · 2022Article
- Cognitive and Neuropsychiatric Impairment in Dystonia.Current neurology and neuroscience reports · 2022Review
- Non-motor phenotypic subgroups in adult-onset idiopathic, isolated, focal cervical dystonia.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
22 authors at 15 institutions in 3 countries.
Funding
Abstract
backgroundNon-motor symptoms are well established phenotypic components of adult-onset idiopathic, isolated, focal cervical dystonia (AOIFCD). However, improved understanding of their clinical heterogeneity is needed to better target therapeutic intervention. Here, we examine non-motor phenotypic features to identify possible AOIFCD subgroups.
methodsParticipants diagnosed with AOIFCD were recruited via specialist neurology clinics (dystonia wales: n = 114, dystonia coalition: n = 183). Non-motor assessment included psychiatric symptoms, pain, sleep disturbance, and quality of life, assessed using self-completed questionnaires or face-to-face assessment. Both cohorts were analyzed independently using Cluster, and Bayesian multiple mixed model phenotype analyses to investigate the relationship between non-motor symptoms and determine evidence of phenotypic subgroups.
resultsIndependent cluster analysis of the two cohorts suggests two predominant phenotypic subgroups, one consisting of approximately a third of participants in both cohorts, experiencing increased levels of depression, anxiety, sleep impairment, and pain catastrophizing, as well as, decreased quality of life. The Bayesian approach reinforced this with the primary axis, which explained the majority of the variance, in each cohort being associated with psychiatric symptomology, and also sleep impairment and pain catastrophizing in the Dystonia Wales cohort.
conclusionsNon-motor symptoms accompanying AOIFCD parse into two predominant phenotypic sub-groups, with differences in psychiatric symptoms, pain catastrophizing, sleep quality, and quality of life. Improved understanding of these symptom groups will enable better targeted pathophysiological investigation and future therapeutic intervention.
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