Evidence map›Paper›PMID 34291405›Full record

ArticleFish physiology and biochemistry2021

Evaluation of ibuprofen contamination in local urban rivers and its effects on immune parameters of juvenile grass carp.

Na Zhang, Xuelian Liu, Longjing Pan, Xiang Zhou, Liang Zhao, Xinyi Mou, Hong Zhou, Jianyu Liu, Xinyan Wang

Abstract read
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In one paragraph

Article in Fish physiology and biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The protective effect ofFrontiers in immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Na ZhangCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Xuelian LiuCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Longjing PanCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Xiang ZhouCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Liang ZhaoCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Xinyi MouCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Hong ZhouCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Jianyu LiuXpiscoric Inc., Chengdu, People's Republic of China.
Xinyan WangCenter for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China. wangxyhku@uestc.edu.cn.
University of Electronic Science and Technology of China · CN

Funding

Sichuan Province Science and Technology Support Program 2019JDRC0007
6 · The paper itself

Abstract

Ibuprofen as a non-steroidal anti-inflammatory drug can be detected in the aquatic environments all over the world. This study evaluated the effects of ibuprofen on the immune parameters of juvenile grass carp at the concentration in real environments which were determined by detecting its concentrations in the surface water of local rivers. The concentration of ibuprofen ranged from 13.2 to 95.5 ng/L with a mean value of 47.9 ng/L in the surface water of local rivers detected by solid-phase extraction followed by LC-MS/MS analysis. Accordingly, juvenile grass carp were exposed to 4.8, 48.0 and 480.0 ng/L of ibuprofen for 14 days. The serum lysozyme activity of these fish decreased, while the serum creatinine levels were not affected after the exposure. Moreover, the mRNA expression of interleukin 6 in the skin and interleukin 1 beta and tumor necrosis factor alpha in the gills was enhanced by this exposure. These results collectively suggest that ibuprofen at environmentally relevant concentration can affect the immune parameters of juvenile grass carp, providing an insight into the possibility of this contaminant to modify the immunostatus of fish.

Indexed as

CarpsFish DiseasesAnimal FeedAnimalsChromatography, LiquidDietFish ProteinsIbuprofenImmunity, InnateRiversTandem Mass SpectrometryWaterFish ProteinsIbuprofenWaterEnvironmentally relevant concentrationIbuprofenImmune parametersJuvenile grass carp

Identifiers

PMID34291405
OpenAlexW3186093159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.