Evidence map›Paper›PMID 34291393›Full record

ArticleMolecular biology reports2021

Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.

Yara Ahmed Mohamed, H M Hassaneen, Mohamed A El-Dessouky, Gehan Safwat, Naglaa Abu-Mandil Hassan, Khalda Amr

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yara Ahmed MohamedFaculty of Biotechnology, October University for Modern Sciences and Arts University (MSA), No. 12567, 54 Anwar El-Sadat street, Al-Haram, Giza, Egypt. ymuhammed@msa.edu.eg.ORCID http://orcid.org/0000-0002-1350-9581
H M HassaneenFaculty of Science, Chemistry Department, Cairo University, Giza, Egypt.
Mohamed A El-DessoukyFaculty of Science, Biochemistry Division, Cairo University, Giza, Egypt.ORCID http://orcid.org/0000-0001-5007-5455
Gehan SafwatFaculty of Biotechnology, October University for Modern Sciences and Arts University (MSA), No. 12567, 54 Anwar El-Sadat street, Al-Haram, Giza, Egypt.ORCID http://orcid.org/0000-0002-1671-5778
Naglaa Abu-Mandil HassanMedical Research Division, Biological Anthropology Department, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0002-4710-2341
Khalda AmrHuman Genetics and Genome Research Division, Medical Molecular Genetics Department, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0001-8472-5911
Cairo University · EGNational Research Centre · EGOctober University of Modern Sciences and Arts · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian. MATERIALS AND

methodsA total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR.

resultsWe observed marked overexpression in DYRK1B (p < 0.05) in MetS subjects when compared with the healthy control subjects.

conclusionThis is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.

Indexed as

Gene ExpressionBiomarkersBody Weights and MeasuresCase-Control StudiesCohort StudiesDyrk KinasesEgyptFemaleHumansLipidsMaleMetabolic SyndromeProtein Serine-Threonine KinasesProtein-Tyrosine KinasesBiomarkersDyrk KinasesLipidsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesDYRK1BGene expressionMetabolic syndromeReal Time PCR

Identifiers

PMID34291393
OpenAlexW3184406825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.