ArticleNeurocritical care2022
The Combination of N60 with Mismatch Negativity Improves the Prediction of Awakening from Coma.
Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Clinical efficacy of electroacupuncture stimulation based on mismatch negativity in patients with prolonged disorders of consciousness.Arquivos de neuro-psiquiatria · 2026Trial
- Diagnostic value of mismatch-negativity and P3a event-related potentials for sepsis-associated encephalopathy in non-sedated patients: a pilot study.World journal of emergency medicine · 2026Article
- Prognostic factors in prolonged disorders of consciousness: a narrative review.Reviews in the neurosciences · 2026Review
- Prognostic value of auditory evoked potentials in disorders of consciousness: a systematic literature review.Clinical neurophysiology practice · 2026Review
- Development of a nomogram for predicting the outcome in patients with prolonged disorders of consciousness based on the multimodal evaluative information.BMC neurology · 2025Article
- Mismatch Negativity and P300 in the Diagnosis and Prognostic Assessment of Coma and Other Disorders of Consciousness.Neurocritical care · 2025Article
- Updated information on neuro-prognosticative tools to predict outcomes for patients with hypoxic-ischemic encephalopathy induced by cardiac arrest.Intractable & rare diseases research · 2024Article
- Quantitative EEG reactivity induced by electrical stimulation predicts good outcome in comatose patients after cardiac arrest.Annals of intensive care · 2024Article
- Auditory stimulation and deep learning predict awakening from coma after cardiac arrest.Brain : a journal of neurology · 2023Article
- Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge.Annals of intensive care · 2022Review
- Comatose Patients After Cardiopulmonary Resuscitation: An Analysis Based on Quantitative Methods of EEG Reactivity.Frontiers in neurology · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur objective was to evaluate the use of event-related potentials and the middle-latency somatosensory evoked potential (MLSEP) for the prediction of awakening in coma, determine the evaluation day that evoked potentials (EPs) best predict an awakening outcome, and determine whether the mismatch negativity (MMN) combined with the MLSEP, when recorded at 7 days after coma, improved the prediction of awakening from coma.
methodsDesign prospective blinded cohort study. Setting neurointensive care unit of a university hospital. Patients 113 consecutive patients who were severely comatose, whose etiologies of coma included stroke (65 patients), hypoxic-ischemic encephalopathy (28 patients), intracranial infection (6 patients), and other (14 patients). Interventions none. Measurements we gathered Glasgow Coma Scale scores and recorded EPs for all patients who were comatose at 7, 14, and 30 days after coma onset, unless the patients returned to consciousness. The EPs examined included the MLSEP, the middle-latency auditory evoked potential, the N100, and the MMN. With telephone follow-up after 3 months, the patients were classified as awakening or nonawakening according to Glasgow Outcome Scale.
resultsWhen predicting an awakening outcome, at least the unilateral presence of the N60 had the highest sensitivity (82.7%), whereas the presence of the MMN showed the highest specificity (82.0%). The area under the receiver operating characteristic curve for the EPs were high at 7 days after coma onset. At 7 days after coma onset, the combination of the N60 and MMN offered good predictive performance for awakening (area under the receiver operating characteristic curve = 0.852, 95% confidence interval 0.765-0.940), with increased sensitivity (70.0%) and improved specificity (91.7%).
conclusionsThe N60 and MMN were the strongest prognostic factors for an awakening outcome. Furthermore, at 7 days after coma onset, the combination of the N60 and MMN improved the prediction of an awakening outcome in patients who were comatose.
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