Evidence map›Paper›PMID 34291364›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2022

The Effect of Facility Volume on Survival Following Proctectomy for Rectal Cancer.

Vanessa M Welten, Kerollos N Wanis, Arin L Madenci, Adam C Fields, Pamela W Lu, Robert A Malizia, James Yoo, Joel E Goldberg, Jennifer L Irani, Ronald Bleday and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Vanessa M WeltenDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA. vwelten@partners.org.ORCID 0000-0002-8775-5857
Kerollos N WanisDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, MA, 02115, Boston, USA.
Arin L MadenciDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Adam C FieldsDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Pamela W LuDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Robert A MaliziaDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
James YooDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Joel E GoldbergDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Jennifer L IraniDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Ronald BledayDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Nelya MelnitchoukDivision of General and Gastrointestinal Surgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, Boston, USA.
Brigham and Women's Hospital · USBoston University · US

Funding

A Contextual Approach to Understanding Operative Volume and MortalityF32AG064831 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MADENCI, ARIN L. · 2019 to 2019
$57k
NIA NIH HHS F32 AG064831
6 · The paper itself

Abstract

backgroundPrior studies assessing colorectal cancer survival have reported better outcomes when operations are performed at high-volume centers. These studies have largely been cross-sectional, making it difficult to interpret their estimates. We aimed to assess the effect of facility volume on survival following proctectomy for rectal cancer.

methodsUsing data from the National Cancer Database, we included all patients with complete baseline information who underwent proctectomy for non-metastatic rectal cancer between 2004 and 2016. Facility volume was defined as the number of rectal cancer cases managed at the treating center in the calendar year prior to the patient's surgery. Overall survival estimates were obtained for facility volumes ranging from 10 to 100 cases/year. Follow-up began on the day of surgery and continued until loss to follow-up or death.

resultsA total of 52,822 patients were eligible. Patients operated on at hospitals with volumes of 10, 30, and 50 cases/year had similar distributions of grade, clinical stage, and neoadjuvant therapies. 1-, 3-, and 5-year survival all improved with increasing facility volume. One-year survival was 94.0% (95% CI: 93.7, 94.3) for hospitals that performed 10 cases/year, 94.5% (95% CI: 94.2, 94.7) for 30 cases/year, and 94.8% (95% CI: 94.5, 95.0) for 50 cases/year. Five-year survival was 68.9% (95% CI: 68.0, 69.7) for hospitals that performed 10 cases/year, 70.8% (95% CI: 70.1, 71.5) for 30 cases/year, and 72.0% (95% CI: 71.2, 72.8) for 50 cases/year.

conclusionsTreatment at a higher volume facility results in improved survival following proctectomy for rectal cancer, though the small benefits are less profound than previously reported.

Indexed as

ProctectomyRectal NeoplasmsCross-Sectional StudiesHumansNeoadjuvant TherapyNeoplasm StagingRetrospective StudiesCancerProctectomyRectalSurvivalVolume

Identifiers

PMID34291364
PMCPMC13003753
OpenAlexW3183996135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.