Evidence map›Paper›PMID 34291145›Full record

ArticleSoftwareX

FM-Track: A fiducial marker tracking software for studying cell mechanics in a three-dimensional environment.

Emma Lejeune, Alex Khang, Jacob Sansom, Michael S Sacks

Abstract read
In one paragraph

Article in SoftwareX. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emma LejeuneJames T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin TX, United States.
Alex KhangJames T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin TX, United States.
Jacob SansomJames T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin TX, United States.
Michael S SacksJames T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin TX, United States.

Funding

Quantitative Methods for Optimizing IMR RepairR01HL073021 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C, SACKS, MICHAEL S · 2004 to 2022
$7.6M
Remodeling potential of the mitral valve following surgical repairR01HL119297 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI GORMAN, JOSEPH H, SACKS, MICHAEL S · 2013 to 2017
$6.6M
Echocardiography to Predict Recurrent IMR After Surgical Mitral Valve ReplacementR01HL103723 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C, HUNG, JUDY W · 2011 to 2020
$5.3M
Biomechanical Optimization of TE Heart ValvesR01HL068816 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WAGNER, WILLIAM R · 2002 to 2011
$3.1M
Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart ValvesR01HL089750 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI SACKS, MICHAEL S · 2007 to 2010
$3.1M
Biomechanical indicators of bicuspid aortic valve dysfunctionR01HL142504 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI GORMAN, ROBERT C, HSU, MING-CHEN · 2018 to 2021
$2.9M
NHLBI NIH HHS R01 HL068816NHLBI NIH HHS R01 HL073021NHLBI NIH HHS R01 HL089750NHLBI NIH HHS R01 HL103723NHLBI NIH HHS R01 HL119297NHLBI NIH HHS R01 HL142504
6 · The paper itself

Abstract

Tracking the deformation of fiducial markers in the vicinity of living cells embedded in compliant synthetic or biological gels is a powerful means to study cell mechanics and mechanobiology in three-dimensional environments. However, current approaches to track and quantify three-dimensional (3D) fiducial marker displacements remain ad-hoc, can be difficult to implement, and may not produce reliable results. Herein, we present a compact software package entitled "FM-Track," written in the popular Python language, to facilitate feature-based particle tracking tailored for 3D cell micromechanical environment studies. FM-Track contains functions for pre-processing images, running fiducial marker tracking, and post-processing and visualization. FM-Track can thus aid the study of cellular mechanics and mechanobiology by providing an extensible software platform to more reliably extract complex local 3D cell contractile information in transparent compliant gel systems.

Indexed as

Cell mechanicsFiducial markersOpen-source softwareParticle trackingTraction force microscopy

Identifiers

PMID34291145
PMCPMC8291167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.