Evidence map›Paper›PMID 34290876›Full record

ArticleCanadian journal of kidney health and disease2021

Incidence and Outcomes of Acute Kidney Injury in Patients Admitted to Hospital With COVID-19: A Retrospective Cohort Study.

Tyler Pitre, Angela Hong Tian Dong, Aaron Jones, Jessica Kapralik, Sonya Cui, Jasmine Mah, Wryan Helmeczi, Johnny Su, Vivek Patel, Zaka Zia and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. The response of Canada's clinical health research ecosystem to the COVID-19 pandemic.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 1 country.

Tyler PitreDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-3015-0723
Angela Hong Tian DongMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Aaron JonesMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Jessica KapralikDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Sonya CuiMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Jasmine MahDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.
Wryan HelmecziDepartment of Internal Medicine, University of Ottawa, ON, Canada.
Johnny SuDepartment of Family Medicine, McMaster University, Hamilton, ON, Canada.
Vivek PatelMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Zaka ZiaMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Michael MallenderMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Xinxin TangMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Cooper WebbMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Nivedh PatroMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Mats JunekDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
MyLinh DuongDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Terence HoDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Marla K BeauchampSchool of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Andrew P CostaDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Rebecca KruisselbrinkDepartment of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Jennifer L Y TsangMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Michael WalshDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
McMaster University · CAImpact · CADalhousie University · CANiagara Health System · CAPopulation Health Research Institute · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of acute kidney injury (AKI) in patients with COVID-19 and its association with mortality and disease severity is understudied in the Canadian population.

objectiveTo determine the incidence of AKI in a cohort of patients with COVID-19 admitted to medicine and intensive care unit (ICU) wards, its association with in-hospital mortality, and disease severity. Our aim was to stratify these outcomes by out-of-hospital AKI and in-hospital AKI.

designRetrospective cohort study from a registry of patients with COVID-19.

settingThree community and 3 academic hospitals. PATIENTS: A total of 815 patients admitted to hospital with COVID-19 between March 4, 2020, and April 23, 2021. MEASUREMENTS: Stage of AKI, ICU admission, mechanical ventilation, and in-hospital mortality.

methodsWe classified AKI by comparing highest to lowest recorded serum creatinine in hospital and staged AKI based on the Kidney Disease: Improving Global Outcomes (KDIGO) system. We calculated the unadjusted and adjusted odds ratio for the stage of AKI and the outcomes of ICU admission, mechanical ventilation, and in-hospital mortality.

resultsOf the 815 patients registered, 439 (53.9%) developed AKI, 253 (57.6%) presented with AKI, and 186 (42.4%) developed AKI in-hospital. The odds of ICU admission, mechanical ventilation, and death increased as the AKI stage worsened. Stage 3 AKI that occurred during hospitalization increased the odds of death (odds ratio [OR] = 7.87 [4.35, 14.23]). Stage 3 AKI that occurred prior to hospitalization carried an increased odds of death (OR = 5.28 [2.60, 10.73]). LIMITATIONS: Observational study with small sample size limits precision of estimates. Lack of nonhospitalized patients with COVID-19 and hospitalized patients without COVID-19 as controls limits causal inferences.

conclusionsAcute kidney injury, whether it occurs prior to or after hospitalization, is associated with a high risk of poor outcomes in patients with COVID-19. Routine assessment of kidney function in patients with COVID-19 may improve risk stratification.

trial registrationThe study was not registered on a publicly accessible registry because it did not involve any health care intervention on human participants.

Indexed as

acute kidney injuryCanadaCOVID-19KDIGOseverity

Identifiers

PMID34290876
PMCPMC8278450
OpenAlexW3179696141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.