Evidence map›Paper›PMID 34290842›Full record

ArticleBiomicrofluidics2021

Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration.

Scott A Baldwin, Shawn M Van Bruggen, Joseph M Koelbl, Ravikanth Appalabhotla, James E Bear, Jason M Haugh

Open access · greenAbstract read
In one paragraph

Article in Biomicrofluidics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Scott A BaldwinDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.ORCID 0000-0003-2886-9894
Shawn M Van BruggenDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.
Joseph M KoelblDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.
Ravikanth AppalabhotlaDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.
James E BearDepartment of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Jason M HaughDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.ORCID 0000-0002-2476-4027
North Carolina State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Systematic Analysis of the Actin Cytoskeleton and Directed Cell MigrationR35GM130312 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAMES E BEAR · 2019 to 2026
$4.8M
Multiscale Modeling of Wound HealingU01EB018816 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HAUGH, JASON M. · 2014 to 2021
$4.0M
Molecular Biotechnology Training at North Carolina State UniversityT32GM008776 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI KELLY, ROBERT M · 2000 to 2019
$3.9M
NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)T32GM133366 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Jason M. Haugh, Albert Keung · 2020 to 2026
$3.3M
Multi-cue Guidance of Mesenchymal Cell MigrationR01GM141691 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HAUGH, JASON M. · 2021 to 2024
$1.2M
NIBIB NIH HHS U01 EB018816NIGMS NIH HHS R01 GM141691NIGMS NIH HHS R35 GM130312NIGMS NIH HHS T32 GM008776NIGMS NIH HHS T32 GM133366
6 · The paper itself

Abstract

Microfluidics approaches have gained popularity in the field of directed cell migration, enabling control of the extracellular environment and integration with live-cell microscopy; however, technical hurdles remain. Among the challenges are the stability and predictability of the environment, which are especially critical for the observation of fibroblasts and other slow-moving cells. Such experiments require several hours and are typically plagued by the introduction of bubbles and other disturbances that naturally arise in standard microfluidics protocols. Here, we report on the development of a passive pumping strategy, driven by the high capillary pressure and evaporative capacity of paper, and its application to study fibroblast chemotaxis. The paper pumps-

Identifiers

PMID34290842
PMCPMC8282348
OpenAlexW3181339778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.