Evidence map›Paper›PMID 34290702›Full record

ArticleFrontiers in immunology2021

Antibody Subclass and Glycosylation Shift Following Effective TB Treatment.

Patricia S Grace, Sepideh Dolatshahi, Lenette L Lu, Adam Cain, Fabrizio Palmieri, Linda Petrone, Sarah M Fortune, Tom H M Ottenhoff, Douglas A Lauffenburger, Delia Goletti and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Article
  3. Tuberculosis treatment and cytotoxic immune signatures: a longitudinal study.Journal of clinical tuberculosis and other mycobacterial diseases · 2026
    Article
  4. Glycosylation profile ofiScience · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Glycosylation in kidney diseases.Precision clinical medicine · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Antigen specificity shapes antibody functions in tuberculosis.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Patricia S GraceRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, United States.
Sepideh DolatshahiDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Lenette L LuDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Adam CainRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, United States.
Fabrizio PalmieriClinical Department, National Institute for Infectious Diseases (INMI), IRCCS L. Spallanzani, Rome, Italy.
Linda PetroneDepartment of Epidemiology and Preclinical Research, National Institute for Infectious Diseases IRCCS (INMI) L. Spallanzani, Rome, Italy.
Sarah M FortuneDepartment of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, United States.
Tom H M OttenhoffDepartment of Infectious Disease, Leiden University Medical Center, Leiden, Netherlands.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Delia GolettiDepartment of Epidemiology and Preclinical Research, National Institute for Infectious Diseases IRCCS (INMI) L. Spallanzani, Rome, Italy.
Simone A JoostenDepartment of Infectious Disease, Leiden University Medical Center, Leiden, Netherlands.
Galit AlterRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, United States.
Ragon Institute of MGH, MIT and Harvard · USIstituti di Ricovero e Cura a Carattere Scientifico · ITLeiden University Medical Center · NLHarvard University · USIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITMassachusetts Institute of Technology · USThe University of Texas Southwestern Medical Center · USUniversity of Virginia · US

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Antibody Mediated Mechanisms of Immune Modulation in TuberculosisK08AI130357 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI LU, LENETTE · 2017 to 2021
$984k
NIAID NIH HHS K08 AI130357NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

With an estimated 25% of the global population infected with

Indexed as

Antibodies, BacterialAntigens, BacterialAntitubercular AgentsFemaleGlycosylationHost-Pathogen InteractionsHumansImmunoglobulin Fc FragmentsImmunoglobulin GKiller Cells, NaturalLatent TuberculosisMaleMycobacterium tuberculosisNeutrophilsPhagocytosisPolysaccharidesAntibodies, BacterialAntigens, BacterialAntitubercular AgentsImmunoglobulin Fc FragmentsImmunoglobulin GPolysaccharidesantibodiesFc-glycosylationIgG4TB therapytuberculosis

Identifiers

PMID34290702
PMCPMC8287567
OpenAlexW3184731290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.