Evidence map›Paper›PMID 34290668›Full record

ArticleFrontiers in endocrinology2021

Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling.

Hui-Hui Wang, Jia-Ni Ma, Xiao-Rong Zhan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 93 citations in OpenAlex.

  1. Mechanistic insights into ferroptosis in thyroid cancer and its therapeutic implications.Apoptosis : an international journal on programmed cell death · 2026
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  19. CircDUSP22 Attenuates the Ferroptosis of Prostate Cancer CellsCombinatorial chemistry & high throughput screening · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hui-Hui WangDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jia-Ni MaDepartment of Endocrinology, Qiqihar First Hospital, Qiqihar, China.
Xiao-Rong ZhanDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
First Affiliated Hospital of Harbin Medical University · CNQiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an emerging programmed cell death distinguished from apoptosis and autophagy and plays essential roles in tumorigenesis. Thyroid cancer is a prevalent endocrine tumor, but the molecular mechanism of ferroptosis during thyroid cancer development remains unclear. Here, we identified the critical function of circular RNA circ_0067934 in repressing ferroptosis of thyroid cancer cells. Our data showed that the ferroptosis activator erastin decreased thyroid cancer cell viabilities, while the circ_0067934 shRNA further attenuated erastin-inhibited cell viabilities. The silencing of circ_0067934 enhanced the levels of ferroptosis-related markers, including Fe

Indexed as

FerroptosisGene Expression Regulation, NeoplasticAmino Acid Transport System y+AnimalsApoptosisBiomarkers, TumorCell ProliferationHumansMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsRNA, CircularThyroid NeoplasmsTumor Cells, CulturedAmino Acid Transport System y+Biomarkers, TumorMicroRNAsMIR545 microRNA, humanRNA, CircularSLC7A11 protein, humancirc_0067934ferroptosismiR-545-3pSLC7A11thyroid cancer

Identifiers

PMID34290668
PMCPMC8287831
OpenAlexW3184827529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.