Evidence map›Paper›PMID 34290623›Full record

ArticleFrontiers in physiology2021

Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid

Jorge Sánchez, Giorgio Luongo, Mark Nothstein, Laura A Unger, Javier Saiz, Beatriz Trenor, Armin Luik, Olaf Dössel, Axel Loewe

Abstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge SánchezInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.
Giorgio LuongoInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.
Mark NothsteinInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.
Laura A UngerInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.
Javier SaizCentro de Investigación e Innovación en Bioingeniería (Ci2B), Universitàt Politècnica de València, Valencia, Spain.
Beatriz TrenorCentro de Investigación e Innovación en Bioingeniería (Ci2B), Universitàt Politècnica de València, Valencia, Spain.
Armin LuikMedizinische Klinik IV, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Olaf DösselInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.
Axel LoeweInstitute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to the isolation of the pulmonary veins, fibrotic sites are considered a suitable target for catheter ablation. However, it remains an open challenge to find fibrotic areas and to differentiate their density and transmurality. This study aims to identify the volume fraction and transmurality of fibrosis in the atrial substrate. Simulated cardiac electrograms, combined with a generalized model of clinical noise, reproduce clinically measured signals. Our hybrid dataset approach combines

Indexed as

atrial fibrillationbidomaincardiac modelingdensityfibrosismachine learningtransmurality

Identifiers

PMID34290623
PMCPMC8287829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.