Evidence map›Paper›PMID 34290596›Full record

ArticleFrontiers in synaptic neuroscience2021

Reducing Auditory Nerve Excitability by Acute Antagonism of Ca

Amit Walia, Choongheon Lee, Jared Hartsock, Shawn S Goodman, Roland Dolle, Alec N Salt, Jeffery T Lichtenhan, Mark A Rutherford

Open access · goldAbstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Grand Challenge at the Frontiers of Synaptic Neuroscience.Frontiers in synaptic neuroscience · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amit WaliaDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Choongheon LeeDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Jared HartsockDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Shawn S GoodmanDepartment of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, United States.
Roland DolleDepartment of Biochemistry and Molecular Biophysics, Washington University Center for Drug Discovery, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Alec N SaltDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Jeffery T LichtenhanDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Mark A RutherfordDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · USUniversity of Iowa · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
DEVELOPMENT OF CLINICIAN/RESEARCHERS IN ACADEMIC ENTT32DC000022 · NIDCD · WASHINGTON UNIVERSITY · PI PICCIRILLO, JAY F. · 1989 to 2022
$5.6M
ORIGINS OF PHYSIOLOGICAL MEASUREMENTS FROM THE EARR01DC014997 · NIDCD · WASHINGTON UNIVERSITY · PI LICHTENHAN, JEFFERY · 2016 to 2020
$1.6M
NCATS NIH HHS UL1 TR002345NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R01 DC014997NIDCD NIH HHS T32 DC000022
6 · The paper itself

Abstract

Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and Ca

Indexed as

auditory nerve fiberblood labyrinth barrierCa2+-permeable AMPA receptorcochlear synapsehearing protectionIEM-1460 and IEM-1925intracochlear drugnon-competitive open-channel block

Identifiers

PMID34290596
PMCPMC8287724
OpenAlexW3186115535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.