Evidence map›Paper›PMID 34290459›Full record

ArticleTetrahedron2021

Geminal Repulsion Disrupts Diels-Alder Reactions of Geminally Substituted Cyclopentadienes and 4

Brian J Levandowski, Nile S Abularrage, Ronald T Raines

Open access · greenAbstract read
In one paragraph

Article in Tetrahedron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Taming the 1,5-sigmatropic shift across protonated spirocyclic 4Journal of physical organic chemistry · 2024
    Article
  2. Computational study of an oxetane 4Tetrahedron letters · 2023
    Article
  3. Article
  4. Bioorthogonal 4Chemical communications (Cambridge, England) · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brian J LevandowskiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Nile S AbularrageDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Ronald T RainesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Massachusetts Institute of Technology · US

Funding

STRUCTURE--FUNCTION ANALYSIS OF RIBONUCLEASE AR01GM044783 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RAINES, RONALD T · 1990 to 2021
$7.1M
Developing Cyclopentadiene as a Reagent in Bioorthogonal ChemistryF32GM137543 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVANDOWSKI, BRIAN · 2020 to 2022
$157k
NIGMS NIH HHS F32 GM137543NIGMS NIH HHS R01 GM044783
6 · The paper itself

Abstract

We have experimentally and computationally explored the sluggish Diels-Alder reactivities of the geminally substituted 5,5-dimethylcyclopentadiene and 5,5-dimethyl-2,3-diazacyclopentadiene (4,4-dimethyl-4

Indexed as

Click ChemistryCycloadditionDensity Functional TheoryDiels–AlderKinetics

Identifiers

PMID34290459
PMCPMC8291746
OpenAlexW3158796639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.