ArticleMolecular psychiatry2021
5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.
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Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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32citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Unravelling the role of the gut microbiome in antipsychotic-induced weight gain and metabolic dysfunction in humans and rodents: A systematic review.Dialogues in clinical neuroscience · 2026Pooled it
- Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice.Nature neuroscience · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.Endocrinology · 2026Article
- A large-scale concordance study of toxicity findings across preclinical species and humans for small molecules and biologics.Frontiers in toxicology · 2026Article
- The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression.Translational psychiatry · 2025Article
- Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice.Nature metabolism · 2025Article
- GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.Nature metabolism · 2025Article
- Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.Metabolism: clinical and experimental · 2025Article
- Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects.World journal of psychiatry · 2025Article
- Pharmacovigilance study on old drugs repurposed for rare diseases across different indications: the case of fenfluramine.Frontiers in pharmacology · 2025Article
- Impact of Antidepressants on Weight Gain: Underlying Mechanisms and Mitigation Strategies.Archives of clinical and biomedical research · 2025Article
- Mechanisms of gut microbiota in host fat deposition: metabolites, signaling pathways, and translational applications.Frontiers in microbiology · 2025Review
- Optogenetic activation of serotonergic neurons changes masticatory movement in freely moving mice.Scientific reports · 2024Article
- Canonical transient receptor potential channels and hypothalamic control of homeostatic functions.Journal of neuroendocrinology · 2024Review
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
- SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Light-Responsive Neural Circuit Suppresses Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.Endocrinology · 2024Article
Corrections and comments
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Authors and funding
24 authors at 9 institutions in 3 countries.
Yanlin He *Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5471-9016
Xing Cai *Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Hailan LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Krisitine M CondeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Pingwen XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Yongxiang LiGuangdong Laboratory of Lingnan Modern Agriculture and Guangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangdong, China.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Meng YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Yang HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Hesong LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Chen LiangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Tingting YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kaifan YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Julia WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0343-9820
Rong ZhengChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Feng LiuDepartments of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, USA.
Zheng SunDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6858-0633
Lora HeislerRowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK.
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4561-2540
Canjun ZhuGuangdong Laboratory of Lingnan Modern Agriculture and Guangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangdong, China.
Gang ShuGuangdong Laboratory of Lingnan Modern Agriculture and Guangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangdong, China. shugang@scau.edu.cn.ORCID http://orcid.org/0000-0002-1321-4396
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. yongx@bcm.edu.ORCID http://orcid.org/0000-0002-4908-1572
Children's Nutrition Research Center at Baylor College of Medicine · USSouth China Agricultural University · CNBaylor College of Medicine · USPennington Biomedical Research Center · USBrown Foundation · USKunming Institute of Zoology · CNThe University of Texas Health Science Center at San Antonio · USUniversity of Aberdeen · GBUniversity of Illinois Chicago · US
Funding
UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ROSENMUND, CHRISTIAN · 1988 to 2013
$29.4MThe role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Jacqueline M Stephens · 2020 to 2026
$18.4MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2018 to 2022
$7.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., NELSON, DAVID LOREN · 2014 to 2019
$7.8MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2MGender-Specific Effects of Arsenic in DiabetesR01ES027544 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2021
$2.2MEpigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0MHypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9MBiotechnology and Biological Sciences Research Council BB/K001418/1Biotechnology and Biological Sciences Research Council BB/NO17838/1Medical Research Council MC/PC/15077Medical Research Council MC_PC_15077NHLBI NIH HHS R01 HL153320NICHD NIH HHS P30 HD024064NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NICHD NIH HHS U54 HD090255NIDDK NIH HHS K01 DK119471NIDDK NIH HHS P01 DK113954NIDDK NIH HHS R00 DK107008NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK111436NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK125480NIDDK NIH HHS R56 DK109194NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R01 ES027544NIGMS NIH HHS P20 GM135002NINDS NIH HHS R21 NS108091
Abstract
Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT
Indexed as
HungerSerotoninDorsal Raphe NucleusNeuronsVentral Tegmental AreaSerotonin
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