ArticleMolecular psychiatry2021
Exploring the genetic heterogeneity in major depression across diagnostic criteria.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional features of treatment-resistant depression: A systematic review and exploratory coordinate-based meta-analysis of neuroimaging studies.Psychiatry and clinical neurosciences · 2023Pooled it
- Multiomic single-nucleus profiling reveals cell-type-specific epigenetic and transcriptional dysregulation in major depressive disorder brain.The international journal of neuropsychopharmacology · 2026Article
- No precision psychiatry without clinical precision.Molecular psychiatry · 2026Article
- Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.Psychological medicine · 2025Article
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- Major depressive disorder on a neuromorphic continuum.Nature communications · 2025Article
- The genetics of severe depression.Molecular psychiatry · 2025Review
- Association between the functional brain network and antidepressant responsiveness in patients with major depressive disorders: a resting-state EEG study.Psychological medicine · 2025Article
- Exploring Gender Differences in the Relationship Between Thyroid Function and Aggressive and Impulsive Behaviors in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- An adaptive multi-graph neural network with multimodal feature fusion learning for MDD detection.Scientific reports · 2024Article
- Treatment-resistant depression: molecular mechanisms and management.Molecular biomedicine · 2024Review
- Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.Nature communications · 2024Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder.Nature genetics · 2023Article
- Heterogeneous brain dynamic functional connectivity patterns in first-episode drug-naive patients with major depressive disorder.Human brain mapping · 2023Article
- New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.PloS one · 2023Article
- The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).Frontiers in epidemiology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Major depressive disorder (MDD) is defined differently across genetic research studies and this may be a key source of heterogeneity. While previous literature highlights differences between minimal and strict phenotypes, the components contributing to this heterogeneity have not been identified. Using the cardinal symptoms (depressed mood/anhedonia) as a baseline, we build MDD phenotypes using five components-(1) five or more symptoms, (2) episode duration, (3) functional impairment, (4) episode persistence, and (5) episode recurrence-to determine the contributors to such heterogeneity. Thirty-two depression phenotypes which systematically incorporate different combinations of MDD components were created using the mental health questionnaire data within the UK Biobank. SNP-based heritabilities and genetic correlations with three previously defined major depression phenotypes were calculated (Psychiatric Genomics Consortium (PGC) defined depression, 23andMe self-reported depression and broad depression) and differences between estimates analysed. All phenotypes were heritable (h
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