Evidence map›Paper›PMID 34290368›Full record

ArticleMolecular psychiatry2021

Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model.

Matthew R Bruce, Karen L Jones, Anthony C Vernon, Jill L Silverman, Jacqueline N Crawley, Jacob Ellegood, Jason P Lerch, Judy Van de Water

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Matthew R BruceDepartment of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-6943-1410
Karen L JonesDepartment of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA.
Anthony C VernonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7305-1069
Jill L SilvermanMIND Institute, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9357-5476
Jacqueline N CrawleyMIND Institute, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-1224-995X
Jacob EllegoodMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1504-3321
Jason P LerchMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada.
Judy Van de WaterDepartment of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA. javandewater@ucdavis.edu.ORCID http://orcid.org/0000-0003-1193-5875
University of California, Davis · USHospital for Sick Children · CAKing's College London · GBUniversity of Toronto · CA

Funding

THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT - ADMINISTRATIVE SUPPLEMENTR01ES015359 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2007 to 2019
$13.8M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CRAWLEY, JACQUELINE N · 2013 to 2019
$8.5M
Medical Research Council MR/N026063/1NICHD NIH HHS P50 HD103526NICHD NIH HHS U54 HD079125NIEHS NIH HHS P01 ES011269NIEHS NIH HHS R01 ES015359
6 · The paper itself

Abstract

Immunoglobulin G (IgG) autoantibodies reactive to fetal brain proteins in mothers of children with ASD have been described by several groups. To understand their pathologic significance, we developed a mouse model of maternal autoantibody related ASD (MAR-ASD) utilizing the peptide epitopes from human autoantibody reactivity patterns. Male and female offspring prenatally exposed to the salient maternal autoantibodies displayed robust deficits in social interactions and increased repetitive self-grooming behaviors as juveniles and adults. In the present study, neuroanatomical differences in adult MAR-ASD and control offspring were assessed via high-resolution ex vivo magnetic resonance imaging (MRI) at 6 months of age. Of interest, MAR-ASD mice displayed significantly larger total brain volume and of the 159 regions examined, 31 were found to differ significantly in absolute volume (mm

Indexed as

Autism Spectrum DisorderAnimalsAutoantibodiesBrainDisease Models, AnimalEpitopesFemaleMaleMiceAutoantibodiesEpitopes

Identifiers

PMID34290368
PMCPMC8776898
OpenAlexW3184928700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.