ArticleCommunications biology2021
Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- PlantInternational journal of molecular sciences · 2026Review
- Supercritical COFoods (Basel, Switzerland) · 2026Article
- Key Dietary Flavonoids: Insights into Their Structural Characteristics, Antioxidant and Anti-Inflammatory Activities, and Potential as Neuroprotective Agents.Molecules (Basel, Switzerland) · 2026Review
- Exploring the extraction, antioxidant activities and its stabilities of peanut skins crude proanthocyanidins extract.Scientific reports · 2025Article
- Proanthocyanidin-Conjugated NIR-ΙΙ Nano-Prodrugs for Reversing Drug Resistance in Photothermal Therapy.Molecules (Basel, Switzerland) · 2025Article
- Prebiotic-like Effects of Proanthocyanidin-Rich Aronia Extract Supplementation on Gut Microbiota Composition and Function in the Twin-M-SHIMEPharmaceuticals (Basel, Switzerland) · 2025Article
- Characteristics of Porous Starch from Lotus Seeds Using Dextranase: Protection and Sustained Release of Proanthocyanidins.Foods (Basel, Switzerland) · 2025Article
- Immunomodulatory properties of dietary polyphenols: a role for combating infections at mucosal surfaces?Microbiome research reports · 2025Review
- Unlocking the mechanistic potential ofJournal of traditional and complementary medicine · 2024Review
- Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear.Heliyon · 2024Review
- Antiglycation potential of metal ions and polyphenolic extract of chickpea on thiol-protease inhibitor: A management for diabetic complications.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective.Current research in food science · 2024Review
- Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway.International journal of molecular sciences · 2023Article
- Engineering Antioxidant Surfaces for Titanium-Based Metallic Biomaterials.Journal of functional biomaterials · 2023Review
- Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials.Antioxidants (Basel, Switzerland) · 2023Review
- Anti-Inflammatory, Anti-Bacterial, and Anti-Fungal Activity of Oligomeric Proanthocyanidins and Extracts Obtained from Lignocellulosic Agricultural Waste.Molecules (Basel, Switzerland) · 2023Article
- Phenolic Fraction from Peanut (Food and bioprocess technology · 2023Review
- Analysis of Proanthocyanidins in Plant Materials Using Hydrophilic Interaction HPLC-QTOF-MS.Molecules (Basel, Switzerland) · 2022Article
- Garlic-Derived Organosulfur Compounds Regulate Metabolic and Immune Pathways in Macrophages and Attenuate Intestinal Inflammation in Mice.Molecular nutrition & food research · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proanthocyanidins (PAC) are dietary compounds that have been extensively studied for beneficial health effects due to their anti-inflammatory properties. However, the structure-function relationships of PAC and their mode-of-action remain obscure. Here, we isolated a wide range of diverse PAC polymer mixtures of high purity from plant material. Polymer size was a key factor in determining the ability of PAC to regulate inflammatory cytokine responses in murine macrophages. PAC polymers with a medium (9.1) mean degree of polymerization (mDP) induced substantial transcriptomic changes, whereas PAC with either low (2.6) or high (12.3) mDP were significantly less active. Short-term oral treatment of mice with PAC modulated gene pathways connected to nutrient metabolism and inflammation in ileal tissue in a polymerization-dependent manner. Mechanistically, the bioactive PAC polymers modulated autophagic flux and inhibited lipopolysaccharide-induced autophagy in macrophages. Collectively, our results highlight the importance of defined structural features in the health-promoting effects of PAC-rich foods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.