ArticleScientific reports2021
The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study.Communications medicine · 2026Article
- Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study.Pediatric obesity · 2025Article
- Article
- Breastfeeding in infancy and cardiovascular disease in middle-aged and older adulthood: a prospective study of 0.36 million UK Biobank participants.The journal of nutrition, health & aging · 2024Article
- Early-life origin of prostate cancer through deregulation of miR-206 networks in maternally malnourished offspring rats.Scientific reports · 2023Article
- Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol.BMJ open · 2023Article
- Australian parental perceptions of genomic newborn screening for non-communicable diseases.Frontiers in genetics · 2023Article
- A Final Frontier in Environment-Genome Interactions? Integrated, Multi-Omic Approaches to Predictions of Non-Communicable Disease Risk.Frontiers in genetics · 2022Review
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8 authors.
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Abstract
It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.
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