ArticleScientific reports2021
Genetic overlap and causal associations between smoking behaviours and mental health.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- Smoking Initiation, Age at Onset of Symptoms and Suicide Attempts Among Patients With Bipolar Disorder: Comparisons With Non-Psychiatric Adults.Bipolar disorders · 2026Article
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Association of educational attainment with mental disorders and the mediation role of lifestyle factors: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Smoking in Substance Use Disorder Patients: Prevalence, Comorbidities, Impulsivity, and Patterns of Readiness to Change.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Disentangling the effects of nicotine versus non-nicotine constituents of tobacco smoke on major depressive disorder: A multivariable Mendelian randomisation study.Addiction (Abingdon, England) · 2025Article
- Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK.The lancet. Psychiatry · 2025Observational
- Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.Bipolar disorders · 2025Article
- Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study.Molecular psychiatry · 2025Article
- Survey and analysis of the prevalence of tobacco use among patients with severe mental illness at a tertiary specialized psychiatric medical center in China.Frontiers in psychiatry · 2025Article
- Psychiatric disorders endorsed by trauma-exposed premenopausal women enrolled in a cardiovascular research study: a 2-year report.Discover mental health · 2024Article
- Association between electronic nicotine product use and subsequent first episode psychosis.Psychiatry research · 2024Article
- Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.Scientific reports · 2024Article
- Schizophrenia mediating the effect of smoking phenotypes on antisocial behavior: A Mendelian randomization analysis.CNS neuroscience & therapeutics · 2024Article
- Use of Tobacco Products and Suicide Attempts Among Elementary School-Aged Children.JAMA network open · 2024Article
- Mendelian randomization studies of depression: evidence, opportunities, and challenges.Annals of general psychiatry · 2023Review
- Development of a Conversational Agent for Individuals Ambivalent About Quitting Smoking: Protocol for a Proof-of-Concept Study.JMIR research protocols · 2023Article
- Evaluation of the causal relationship between smoking and schizophrenia in East Asia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Longitudinal survey of depressive symptoms among university students during the COVID-19 pandemic in Japan.Frontiers in psychology · 2022Article
- Differential trajectories of tobacco smoking in people at ultra-high risk for psychosis: Associations with clinical outcomes.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Cigarette smoking is a modifiable behaviour associated with mental health. We investigated the degree of genetic overlap between smoking behaviours and psychiatric traits and disorders, and whether genetic associations exist beyond genetic influences shared with confounding variables (cannabis and alcohol use, risk-taking and insomnia). Second, we investigated the presence of causal associations between smoking initiation and psychiatric traits and disorders. We found significant genetic correlations between smoking and psychiatric disorders and adult psychotic experiences. When genetic influences on known covariates were controlled for, genetic associations between most smoking behaviours and schizophrenia and depression endured (but not with bipolar disorder or most psychotic experiences). Mendelian randomization results supported a causal role of smoking initiation on psychiatric disorders and adolescent cognitive and negative psychotic experiences, although not consistently across all sensitivity analyses. In conclusion, smoking and psychiatric disorders share genetic influences that cannot be attributed to covariates such as risk-taking, insomnia or other substance use. As such, there may be some common genetic pathways underlying smoking and psychiatric disorders. In addition, smoking may play a causal role in vulnerability for mental illness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.