ArticleScientific reports2021
A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Surface circumferential spinal cord recording in freely moving rodents.Nature communications · 2026Article
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Comparison of activation and selectivity in dorsal and ventral epidural spinal cord stimulation in rats: a computational modeling study.Scientific reports · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- The ins and outs of spinal cord stimulation.Brain communications · 2025Article
- Ventral epidural stimulation for motor recovery after spinal cord injury: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Flexible circumferential bioelectronics to enable 360-degree recording and stimulation of the spinal cord.Science advances · 2024Article
- Stochastic electrical stimulation of the thoracic or cervical regions with surface electrodes facilitates swallow in rats.Frontiers in neurology · 2024Article
- Thin-film implants for bioelectronic medicine.MRS bulletin · 2024Review
- Miniaturized Wirelessly Powered and Controlled Implants for Multisite Stimulation.IEEE transactions on microwave theory and techniques · 2023Article
- Implantable, Programmable, and Wireless Device for Electrical Stimulation of the Dorsal Root Ganglion in Freely-Moving Rats: A Proof of Concept Study.Journal of pain research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Electrical stimulation of the cervical spinal cord is gaining traction as a therapy following spinal cord injury; however, it is difficult to target the cervical motor region in a rodent using a non-penetrating stimulus compared with direct placement of intraspinal wire electrodes. Penetrating wire electrodes have been explored in rodent and pig models and, while they have proven beneficial in the injured spinal cord, the negative aspects of spinal parenchymal penetration (e.g., gliosis, neural tissue damage, and obdurate inflammation) are of concern when considering therapeutic potential. We therefore designed a novel approach for epidural stimulation of the rat spinal cord using a wireless stimulation system and ventral electrode array. Our approach allowed for preservation of mobility following surgery and was suitable for long term stimulation strategies in awake, freely functioning animals. Further, electrophysiology mapping of the ventral spinal cord revealed the ventral approach was suitable to target muscle groups of the rat forelimb and, at a single electrode lead position, different stimulation protocols could be applied to achieve unique activation patterns of the muscles of the forelimb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.