ArticleNature communications2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients.The Journal of infectious diseases · 2024Trial
- Interleukin-6 Downregulates T Helper 17 Cytokines via Indoleamine 2,3-Dioxygenase 1 at the Maternal-Fetal Interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Characterization of multi-stage metabolic alterations in hepatitis B virus-related acute-on-chronic liver failure using high-coverage metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview.Molecular neurobiology · 2026Review
- Metabolic characteristics in hepatocellular carcinoma: amino acid metabolic reprogramming.Molecular cancer · 2026Review
- Microbiota-derived IPA mitigates post-stroke neuroinflammation by inhibiting TREM2-dependent pyroptosis.Journal of neuroinflammation · 2026Article
- High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Review
- From metabolomics to transfusion-associated immunomodulation.Current opinion in immunology · 2025Review
- Review
- Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes.Journal of physiology and biochemistry · 2025Article
- 3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Article
- Interventions in cytokine signaling: novel horizons for psoriasis treatment.Frontiers in immunology · 2025Review
- Integrated multi-omics reveals distinct maternal and neonatal gut microbial and metabolic signatures associated with small for gestational age status.Frontiers in microbiology · 2025Article
- Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis.npj biomedical innovations · 2025Article
- Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells.Cancer immunology, immunotherapy : CII · 2024Review
- Cancer cell metabolism and antitumour immunity.Nature reviews. Immunology · 2024Review
- Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.Cell reports · 2024Article
Corrections and comments
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Authors and funding
35 authors at 12 institutions in 7 countries.
Cristina C ClementDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Sangeetha ThangaswamyDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
Samantha ChalmersDivision of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Raquel FurtadoDivision of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0002-7442-0767
Sheila SpadaDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
Giada MondanelliDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Federica IanniDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Sarah GehrkeDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Marco GargaroDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0003-0645-9800
Giorgia ManniDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Luisa Carlota Lopez CaraDepartment of Pharmaceutical & Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.
Peter RungeInstitute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.
Wanxia Li TsaiTranslational Immunology Section, National Institute of Arthritis Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
Sinem KaramanWihuri Research Institute and Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0719-1773
Jorge ArasaInstitute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.
Ruben Fernandez-RodriguezDepartment of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9127-1735
Amanda BeckDepartment of Pathology, Albert Einstein College of Medicine, New York, NY, USA.
Antonio MacchiaruloDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Massimo GadinaTranslational Immunology Section, National Institute of Arthritis Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
Cornelia HalinInstitute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-7899-2850
Francesca FallarinoDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0002-8501-2136
Mihaela SkobeDepartment of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1583-6487
Marc VeldhoenInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.ORCID 0000-0002-1478-9562
Simone MorettiIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia, Italy.ORCID 0000-0001-5599-5613
Silvia FormentiDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8227-8924
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4426-0499
Rajesh K SoniProteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
Roberta GalariniIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia, Italy.
Roccaldo SardellaDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Gregoire LauvauDivision of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0002-3050-2664
Chaim PuttermanDivision of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Kari AlitaloWihuri Research Institute and Translational Cancer Medicine Research Program, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7331-0902
Ursula GrohmannDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy. ursula.grohmann@unipg.it.ORCID 0000-0001-7952-1850
Laura SantambrogioDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. las4011@med.cornell.edu.ORCID 0000-0002-4674-7041
Albert Einstein College of Medicine · USUniversity of Perugia · ITCornell University · USETH Zurich · CHIcahn School of Medicine at Mount Sinai · USIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche · ITNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Helsinki · FIColumbia University Irving Medical Center · USUniversidad de Granada · ESUniversity of Lisbon · PT
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2MTranslational Immunology research: a support for clinical immunological researchZICAR041181 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2025
$31.5MBronx-Einstein Training in Teaching and Research (BETTR), an IRACDA programK12GM102779 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Dianne Cox, Johanna Patricia Daily · 2012 to 2026
$9.2MDEVELOPMENTAL RENAL AND ELECTROLYTE PHYSIOLOGYT32DK007110 · NIDDK · YESHIVA UNIVERSITY · PI KASKEL, FREDERICK JEFFREY, MELAMED, MICHAL L · 1986 to 2021
$5.6MEnhancing Pathogen-specific Memory CD8+ T cell Responses in VivoR01AI103338 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAUVAU, GREGOIRE STEPHANE · 2013 to 2022
$5.2MDYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOMER01AI137198 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTAMBROGIO, LAURA, STERN, LAWRENCE J. · 2018 to 2022
$4.6MMHC class II-restricted immune response in immunosenescenceR01AG045223 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTAMBROGIO, LAURA · 2014 to 2018
$1.7MEnhancing Pathogen-Specific Memory CD8+ T cell Responses In VivoR56AI103338 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LAUVAU, GREGOIRE STEPHANE · 2024 to 2024
$633kDefining Novel Cellular Correlates of Protection Against Human Malaria by CyTOFR21AI138552 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAUVAU, GREGOIRE STEPHANE · 2018 to 2019
$459kIntramural NIH HHS ZIC AR041181NCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI103338NIAID NIH HHS R01 AI137198NIAID NIH HHS R21 AI138552NIAID NIH HHS R56 AI103338NIA NIH HHS R01 AG045223NIDDK NIH HHS T32 DK007110NIGMS NIH HHS K12 GM102779
Abstract
Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-L-kynurenamine (3-HKA) is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8
Indexed as
AnimalsBiogenic AminesCell Line, TumorDendritic CellsDisease Models, AnimalEndothelial CellsHumansImmunomodulationIndoleamine-Pyrrole 2,3,-DioxygenaseInflammationInterferon-gammaKynurenineMiceNephritisNF-kappa BPsoriasis3-hydroxykynurenineBiogenic AminesIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaKynurenineNF-kappa BTryptophan
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