ArticleNature communications2021
Distinct cortical systems reinstate the content and context of episodic memories.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04286776 (Memory Retrieval and Encoding Investigated by Neural Stimulation), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Memory Retrieval and Encoding Investigated by Neural Stimulation
Who cites it
14 citing papers in PubMed.
- The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.PLoS biology · 2026Article
- Article
- Involuntary and voluntary memory retrieval relies on distinct neural representations and oscillatory processes.PLoS biology · 2025Article
- The Effects of External Cue Overlap and Internal Goals on Selective Memory Retrieval as Revealed by Electroencephalographic (EEG) Neural Pattern Reinstatement.The European journal of neuroscience · 2025Article
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Memory consolidation accelerates.Nature neuroscience · 2025Article
- Study-phase reinstatement predicts subsequent recall.Nature neuroscience · 2025Article
- Contextual Influence on Pattern Separation During Encoding.NeuroSci · 2025Article
- Semantic associations restore neural encoding mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Functional and anatomical connectivity predict brain stimulation's mnemonic effects.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Setting boundaries: Development of neural and behavioral event cognition in early childhood.Developmental science · 2023Article
- Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales.Nature communications · 2023Article
- Neural temporal context reinstatement of event structure during memory recall.Journal of experimental psychology. General · 2023Article
- Cue overlap supports preretrieval selection in episodic memory: ERP evidence.Cognitive, affective & behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Episodic recall depends upon the reinstatement of cortical activity present during the formation of a memory. Evidence from functional neuroimaging and invasive recordings in humans suggest that reinstatement organizes our memories by time or content, yet the neural systems involved in reinstating these unique types of information remain unclear. Here, combining computational modeling and intracranial recordings from 69 epilepsy patients, we show that two cortical systems uniquely reinstate the semantic content and temporal context of previously studied items during free recall. Examining either the posterior medial or anterior temporal networks, we find that forward encoding models trained on the brain's response to the temporal and semantic attributes of items can predict the serial position and semantic category of unseen items. During memory recall, these models uniquely link reinstatement of temporal context and semantic content to these posterior and anterior networks, respectively. These findings demonstrate how specialized cortical systems enable the human brain to target specific memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.