Evidence map›Paper›PMID 34290147›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Evolution of a σ-(c-di-GMP)-anti-σ switch.

Maria A Schumacher, Kelley A Gallagher, Neil A Holmes, Govind Chandra, Max Henderson, David T Kysela, Richard G Brennan, Mark J Buttner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria A SchumacherDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710; maria.schumacher@duke.edu mark.buttner@jic.ac.uk.
Kelley A GallagherDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0003-1306-724X
Neil A HolmesDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.
Govind ChandraDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-7882-6676
Max HendersonDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
David T KyselaDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Richard G BrennanDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0001-7647-485X
Mark J ButtnerDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom; maria.schumacher@duke.edu mark.buttner@jic.ac.uk.ORCID 0000-0002-3505-2981

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular levelR35GM130290 · NIGMS · DUKE UNIVERSITY · PI Maria Schumacher · 2019 to 2026
$4.9M
Eliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5M
Biotechnology and Biological Sciences Research Council BB/J004561/1Biotechnology and Biological Sciences Research Council BB/N006852/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000015NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R35 GM130290
6 · The paper itself

Abstract

Filamentous actinobacteria of the genus

Indexed as

ActinobacteriaCrystallography, X-RayCyclic GMPFimbriae, BacterialGene Expression Regulation, BacterialModels, MolecularProtein BindingProtein ConformationProtein DomainsSigma FactorStreptomycesbis(3',5')-cyclic diguanylic acidCyclic GMPSigma Factorc-di-GMP signalingprotein evolutionRsiGsecond messengerStreptomyces

Identifiers

PMID34290147
PMCPMC8325347

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.