Evidence map›Paper›PMID 34290142›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.

Lena M Grass, Jan Wollenhaupt, Tatjana Barthel, Iwan Parfentev, Henning Urlaub, Bernhard Loll, Eberhard Klauck, Haike Antelmann, Markus C Wahl

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. The RNA helicase HrpA rescues collided ribosomes inbioRxiv : the preprint server for biology · 2024
    Article
  4. The intrinsic macrolide resistome ofAntimicrobial agents and chemotherapy · 2024
    Article
  5. Article
  6. Article
  7. Distinct ecological fitness factors coordinated by a conservedProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Regulation of the DEAH/RHA helicase Prp43 by the G-patch factor Pfa1.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Genome-Wide Analysis of Innate Susceptibility Mechanisms ofAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lena M GrassLaboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany.ORCID 0000-0001-6200-1162
Jan WollenhauptMacromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, D-12489 Berlin, Germany.ORCID 0000-0002-3418-5213
Tatjana BarthelLaboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany.ORCID 0000-0002-8747-3112
Iwan ParfentevBioanalytical Mass Spectrometry, Max-Planck-Institut für biophysikalische Chemie, D-37077 Göttingen, Germany.
Henning UrlaubBioanalytical Mass Spectrometry, Max-Planck-Institut für biophysikalische Chemie, D-37077 Göttingen, Germany.ORCID 0000-0003-1837-5233
Bernhard LollLaboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany.ORCID 0000-0001-7928-4488
Eberhard KlauckMicrobiology, Institute of Biology, Freie Universität Berlin, D-14195 Berlin, Germany.
Haike AntelmannMicrobiology, Institute of Biology, Freie Universität Berlin, D-14195 Berlin, Germany.ORCID 0000-0002-1766-4386
Markus C WahlLaboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany; markus.wahl@fu-berlin.de.ORCID 0000-0002-2811-5307
Freie Universität Berlin · DEHelmholtz-Zentrum Berlin für Materialien und Energie · DEMax Planck Institute for Biophysical Chemistry · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many bacteria harbor RNA-dependent nucleoside-triphosphatases of the DEAH/RHA family, whose molecular mechanisms and cellular functions are poorly understood. Here, we show that the

Indexed as

Drug Resistance, BacterialAdenosine DiphosphateAnti-Bacterial AgentsBinding SitesCrystallography, X-RayDEAD-box RNA HelicasesEscherichia coliEscherichia coli ProteinsModels, MolecularProtein ConformationAdenosine DiphosphateAnti-Bacterial AgentsDEAD-box RNA HelicasesEscherichia coli ProteinshrpA protein, E coliantibiotics resistanceco-/posttranscriptional gene regulationRNA-dependent NTPase/RNA helicasestructural biologyX-ray crystallography

Identifiers

PMID34290142
PMCPMC8325345
OpenAlexW3183166236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.