ArticleScience advances2021
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 95 citations in OpenAlex.
- Neurovascular Signaling in the Perivascular Space: Biophysical Principles and Disruption in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Voltage-Dependent Ion Channels in Vascular Endothelial Cells: An Unexpected Signaling Pathway in Non-Excitable Cells.Biomedicines · 2026Review
- A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brain endothelial GαEBioMedicine · 2026Article
- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Cerebral capillary computation.American journal of physiology. Cell physiology · 2026Review
- Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.Nature communications · 2026Article
- Skin capillary endothelial cells form a network of spatiotemporally conserved CabioRxiv : the preprint server for biology · 2026Article
- Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy.Nature biomedical engineering · 2026Article
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- The role of TRPV4 in ischemic stroke.Molecular brain · 2026Review
- Brain Capillary Ion Channels: Physiology and Channelopathies.Physiology (Bethesda, Md.) · 2026Review
- Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels.The Journal of physiology · 2026Article
- Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Frontiers in cellular neuroscience · 2026Review
- PIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Blocking axon-glial mechanotransduction to prevent concussive brain injury.Acta neuropathologica communications · 2025Article
- The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 3 countries.
Thomas A LongdenDepartment of Pharmacology, University of Vermont, Burlington, VT, USA. mark.nelson@uvm.edu thomas.longden@som.umaryland.edu.ORCID http://orcid.org/0000-0002-7950-7677
Amreen MughalDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-0046-2286
Grant W HennigDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0001-7436-9458
Osama F HarrazDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0003-2061-1100
Bo ShuiDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-5744-9886
Frank K LeeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-9306-5190
Jane C LeeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-0557-3900
Shaun ReiningDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Michael I KotlikoffDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Gabriele M KönigInstitute of Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.ORCID http://orcid.org/0000-0003-0003-4916
Evi KostenisMolecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.ORCID http://orcid.org/0000-0001-8284-5514
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-6866-1863
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, USA. mark.nelson@uvm.edu thomas.longden@som.umaryland.edu.ORCID http://orcid.org/0000-0002-6608-8784
University of Vermont · USCornell University · USUniversity of Bonn · DE
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MVermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SIGMON, STACEY C · 2013 to 2022
$21.3MVermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4MImpact of SAH on Parenchymal Arterioles and Neurovascular CouplingP01HL095488 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEPPNER, THOMAS · 2010 to 2014
$11.4MCapillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3MCa2+ Sparks and Urinary Bladder Smooth Muscle ExcitabilityR37DK053832 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2008 to 2017
$3.4MGenetic Resource for Optical SignalingR24HL120847 · NHLBI · CORNELL UNIVERSITY · PI KOTLIKOFF, MICHAEL I. · 2014 to 2018
$3.1MIon Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6MPericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's diseaseR01AG066645 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Thomas A Longden · 2020 to 2026
$2.5MVascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and DiseaseDP2NS121347 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LONGDEN, THOMAS A · 2020 to 2020
$2.3MRegulations of Myoendothelial Function By Signaling Microdomains in HypertensionR01HL121706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2014 to 2017
$1.6MK+ sensing & electrical signaling by Kir channels in brain vasculatureR01HL131181 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2016 to 2018
$1.4MAmerican Heart Association-American Stroke Association 17POST33650030American Heart Association-American Stroke Association 20CDA35310097 - OSAMA HARRAZNCI NIH HHS P30 CA062203NHLBI NIH HHS P01 HL095488NHLBI NIH HHS R01 HL121706NHLBI NIH HHS R01 HL131181NHLBI NIH HHS R24 HL120847NHLBI NIH HHS R35 HL140027NIA NIH HHS R01 AG066645NIDDK NIH HHS R37 DK053832NIGMS NIH HHS P20 GM103644NIGMS NIH HHS P20 GM135007NINDS NIH HHS DP2 NS121347NINDS NIH HHS R01 NS110656
Abstract
Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo imaging in anesthetized mice, we reveal that brain capillary endothelial cells control blood flow through a hierarchy of IP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.