Evidence map›Paper›PMID 34290083›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP

Murat S Durakoglugil, Catherine R Wasser, Connie H Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Murat S DurakoglugilDepartment of Molecular Genetics Murat.Durakoglugil@UTSouthwestern.edu Joachim.herz@UTSouthwestern.edu.ORCID https://orcid.org/0000-0003-4483-8166
Catherine R WasserDepartment of Molecular Genetics.ORCID https://orcid.org/0000-0001-6396-0146
Connie H WongDepartment of Molecular Genetics.
Theresa PohlkampDepartment of Molecular Genetics.ORCID https://orcid.org/0000-0003-3923-1917
Xunde XianInstitute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing 100871, China.ORCID https://orcid.org/0000-0003-3059-1254
Courtney Lane-DonovanWeill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158.
Katja FritschleTechnical University of Munich, 80333 Munich, Germany.
Lea NaestleLudwig-Maximilians University of Munich, 80539, Munich, Germany.
Joachim HerzDepartment of Molecular Genetics Murat.Durakoglugil@UTSouthwestern.edu Joachim.herz@UTSouthwestern.edu.
Ludwig-Maximilians-Universität München · DEPeking University · CNSociety for Neuroscience · USSouthwestern Medical Center · USTechnical University of Munich · DEUniversity of California, San Francisco · US

Funding

Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal DementiR01NS108115 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HAGGARTY, STEPHEN J, HERZ, JOACHIM J · 2018 to 2022
$4.0M
Metabolism of the VLDL receptor and ApoE receptor 2R37HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2010 to 2019
$4.0M
METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2R01HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2000 to 2009
$3.1M
Physiology and Pathophysiology of Apolipoprotein E receptor-2 splicing in Alzheimer's diseaseRF1AG053391 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.4M
Molecular Basis of Synaptic Suppression by ApoER01NS093382 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.0M
NHE6: A Novel Rational Target For Alzheimer's DiseaseF31AG067708 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WONG, CONNIE HUA · 2020 to 2021
$71k
The Role of Reelin in Adult Neuronal Function and Alzheimer's DiseaseF30AG047799 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LANE-DONOVAN, COURTNEY E · 2014 to 2015
$58k
NHLBI NIH HHS R01 HL063762NHLBI NIH HHS R37 HL063762NIA NIH HHS F30 AG047799NIA NIH HHS F31 AG067708NIA NIH HHS RF1 AG053391NINDS NIH HHS R01 NS093382NINDS NIH HHS R01 NS108115
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease marked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Aβ oligomers cause synaptic dysfunction early in AD by enhancing long-term depression (LTD; a paradigm for forgetfulness) via metabotropic glutamate receptor (mGluR)-dependent regulation of striatal-enriched tyrosine phosphatase (STEP

Indexed as

2-Amino-5-phosphonovalerateAnimalsCA1 Region, HippocampalCalciumCells, CulturedCerebral CortexEnzyme InductionLong-Term Synaptic DepressionMemoryMethoxyhydroxyphenylglycolMiceNerve DegenerationNeuronsPatch-Clamp TechniquesPhosphorylationPicrotoxin2-Amino-5-phosphonovalerate3,4-dihydroxyphenylglycolCalciumglutamate receptor ionotropic, AMPA 2MethoxyhydroxyphenylglycolPicrotoxinProtein Tyrosine Phosphatases, Non-ReceptorPtpn5 protein, mouseReceptors, AMPAReceptors, Metabotropic GlutamateRecombinant ProteinsReelin ProteinReln protein, mouseAMPA receptorApoENMDA receptorReelinSTEPsynaptic plasticity

Identifiers

PMID34290083
PMCPMC8412985
OpenAlexW3186780835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.