Evidence map›Paper›PMID 34290080›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep.

Joseph R Winer, Allison Morehouse, Laura Fenton, Theresa M Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L Baker, William J Jagust, Matthew P Walker

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Understanding misophonia from an audiological perspective: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  2. Article
  3. Article
  4. Sleep fragmentation correlates with amyloid beta deposition at brain autopsy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Article
  7. Longitudinal association between sleep and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Sleep trajectories across three cognitive-aging pathways in community older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Joseph R WinerCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720 jwiner@berkeley.edu mpwalker@berkeley.edu.ORCID https://orcid.org/0000-0003-4069-3158
Allison MorehouseCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720.
Laura FentonHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.
Theresa M HarrisonHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.ORCID https://orcid.org/0000-0002-2036-3496
Lylian AyangmaCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720.
Mark ReedCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720.
Samika KumarCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720.
Suzanne L BakerMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720.ORCID https://orcid.org/0000-0003-0209-3127
William J JagustHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.ORCID https://orcid.org/0000-0002-4458-113X
Matthew P WalkerCenter for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720 jwiner@berkeley.edu mpwalker@berkeley.edu.
University of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Tau pathology, sleep disruption, and hippocampal memory decline in older adultsRF1AG054106 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2017 to 2018
$4.7M
Sleep Loss, Human Memory and Brain Plasticity across the LifespanR01AG031164 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2008 to 2019
$4.7M
A sleep electroencephalography biomarker predicting Alzheimer's disease pathologyRF1AG054019 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WALKER, MATTHEW P · 2016 to 2016
$4.1M
Tracking Tau with In Vivo Braak Staging: Longitudinal Analysis of Tau Pathology and Functional Sequelae in Cognitively Healthy Older AdultsF32AG057107 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRISON, THERESA M. · 2017 to 2020
$124k
Relationships between tau pathology, sleep physiology and memory in agingF31AG063428 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WINER, JOSEPH ROBERT · 2019 to 2020
$59k
NIA NIH HHS F31 AG063428NIA NIH HHS F32 AG057107NIA NIH HHS R01 AG031164NIA NIH HHS R01 AG034570NIA NIH HHS RF1 AG054019NIA NIH HHS RF1 AG054106
6 · The paper itself

Abstract

Alzheimer's disease is associated with poor sleep, but the impact of tau and β-amyloid (Aβ) pathology on sleep remains largely unknown. Here, we test the hypothesis that tau and Aβ predict unique impairments in objective and self-perceived human sleep under real-life, free-living conditions. Eighty-nine male and female cognitively healthy older adults received

Indexed as

ActigraphyAgedAged, 80 and overAgingAmyloid beta-PeptidesBrainFemaleHumansMaleNeuropsychological TestsPositron-Emission TomographySelf ReportSleepSurveys and Questionnairestau ProteinsAmyloid beta-Peptidestau ProteinsagingAlzheimer's diseaseamyloidsleeptau

Identifiers

PMID34290080
PMCPMC8425979
OpenAlexW3185524364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.