Evidence map›Paper›PMID 34290022›Full record

ArticleBMJ case reports2021

Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma.

Koichi Hata, Chikara Sakaguchi, Michiko Tsuchiya, Yukio Nagasaka

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Koichi HataDepartment of Internal Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan h-hata@koto.kpu-m.ac.jp.ORCID http://orcid.org/0000-0001-5705-3793
Chikara SakaguchiDepartment of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.
Michiko TsuchiyaDepartment of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.
Yukio NagasakaKyoto Respiratory Center, Rakuwakai Otowa Hospital, Kyoto, Japan.
Rakuwakai Otowa Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Used for a wide range of cancers, nivolumab has been reported to cause immune-related adverse events, including isolated adrenocorticotropic hormone deficiency (IAD). We report an 81-year-old woman with malignant mesothelioma who presented with abdominal pain after eight courses of nivolumab therapy, leading to the diagnosis of nivolumab-induced IAD. We should consider adrenal insufficiency (AI) when a patient on nivolumab complains of abdominal pain and has no other explanatory findings. Infusion-resistant hypotension and hyponatraemia can further suggest AI.

Indexed as

Endocrine System DiseasesMesothelioma, MalignantAbdominal PainAdrenocorticotropic HormoneAged, 80 and overFemaleHumansNivolumabAdrenocorticotropic HormoneNivolumabEndocrine systemPituitary disordersRespiratory cancer

Identifiers

PMID34290022
PMCPMC8296770
OpenAlexW3185967210

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.