Evidence map›Paper›PMID 34289973›Full record

Observational studyThe European respiratory journal2021

Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis.

Amisha V Barochia, Maryann Kaler, Nargues Weir, Elizabeth M Gordon, Debbie M Figueroa, Xianglan Yao, Merte Lemma WoldeHanna, Maureen Sampson, Alan T Remaley, Geraldine Grant and 3 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Advances in metabolic reprogramming of pulmonary fibrosis.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Review
  12. Article
  13. Article
  14. Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Amisha V BarochiaLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA barochiaav@nhlbi.nih.gov.ORCID 0000-0002-7352-6412
Maryann KalerLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.
Nargues WeirLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.
Elizabeth M GordonLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.
Debbie M FigueroaLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.
Xianglan YaoLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.ORCID 0000-0003-0668-0353
Merte Lemma WoldeHannaAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Maureen SampsonClinical Center, NIH, Bethesda, MD, USA.
Alan T RemaleyTranslational Vascular Medicine Branch, NHLBI, NIH, Bethesda, MD, USA.
Geraldine GrantDept of Biology, George Mason University, Manassas, VA, USA.
Scott D BarnettAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Steven D NathanAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Stewart J LevineLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.ORCID 0000-0001-9313-9746
National Institutes of Health · USInova Fairfax Hospital · USGeorge Mason University · USNational Institutes of Health Clinical Center · US

Funding

Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary FibrosisZIAHL006208 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVINE, STEWART · 2016 to 2023
$2.3M
Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

backgroundSerum lipoproteins, such as high-density lipoproteins (HDL), may influence disease severity in idiopathic pulmonary fibrosis (IPF). Here, we investigated associations between serum lipids and lipoproteins and clinical end-points in IPF.

methodsClinical data and serum lipids were analysed from a discovery cohort (59 IPF subjects, 56 healthy volunteers) and validated using an independent, multicentre cohort (207 IPF subjects) from the Pulmonary Fibrosis Foundation registry. Associations between lipids and clinical end-points (forced vital capacity, 6-min walk distance, gender age physiology (GAP) index, death or lung transplantation) were examined using Pearson's correlation and multivariable analyses.

resultsSerum concentrations of small HDL particles measured using nuclear magnetic resonance spectroscopy (S-HDLP

conclusionsHigher serum levels of S-HDLP

Indexed as

Idiopathic Pulmonary FibrosisLung TransplantationHumansSeverity of Illness IndexTidal VolumeVital Capacity

Identifiers

PMID34289973
PMCPMC9389624
OpenAlexW3185322371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.