Trial reportFertility and sterility2021
Male vitamin D status and male factor infertility.
Trial report in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Metabolic and bariatric surgery and male endocrine and reproductive health: a GRADE-assessed meta-analysis.Frontiers in nutrition · 2026Pooled it
- Pooled it
- Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022Pooled it
- Vitamin D in male reproduction: molecular mechanisms and pharmacological perspectives.Frontiers in pharmacology · 2026Review
- Serum 25-Hydroxyvitamin D and Sperm DNA Fragmentation Index In Men Referred For Infertility: A Cross-Sectional Study of 783 Patients.Journal of family & reproductive health · 2025Article
- Association of the uric acid-to-high-density lipoprotein cholesterol ratio with vitamin D deficiency in postmenopausal women: evidence from NHANES 2005-2016.Lipids in health and disease · 2025Article
- The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Association between serum Vitamin D levels and sperm DNA fragmentation index in varicocele patients: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Reducing early pregnancy loss with vitamin DJournal of clinical biochemistry and nutrition · 2025Article
- Machine learning algorithm based on combined clinical indicators for the prediction of infertility and pregnancy loss.Frontiers in endocrinology · 2025Article
- Vitamin D in male sexual functions: unwrapping the sunshine hormone activities in erectile function and beyond.Frontiers in reproductive health · 2025Review
- Reply to Abid et al. Comment on "Aşır et al. Investigation of Vitamin D Levels in Men with Suspected Infertility.Life (Basel, Switzerland) · 2024Article
- Comment on Aşır et al. Investigation of Vitamin D Levels in Men with Suspected Infertility.Life (Basel, Switzerland) · 2024Article
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.Reproductive health · 2024Review
- Investigation of Vitamin D Levels in Men with Suspected Infertility.Life (Basel, Switzerland) · 2024Article
- Clinical predictive value of pre-pregnancy tests for unexplained recurrent spontaneous abortion: a retrospective study.Frontiers in medicine · 2024Article
- The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice.Scientific reports · 2023Article
- On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends.Antioxidants (Basel, Switzerland) · 2023Review
- Is There a Relevant Clinical Impact in Differentiating IdiopathicThe world journal of men's health · 2023Article
- High sperm DNA fragmentation: do we have robust evidence to support antioxidants and testicular sperm extraction to improve fertility outcomes? a narrative review.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility.
designSecondary analysis of a randomized, controlled trial.
settingNine fertility centers in the United States. PATIENT(S): Men (n = 154) with sperm concentration between 5 and 15 million/mL, motility ≤40%, or normal morphology ≤4% were eligible. Female partners were ovulatory, ≤40 years old, and had documented tubal patency. INTERVENTION(S): Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels. They were randomly assigned to receive a vitamin formulation including vitamin D 2,000 IU daily or placebo for up to 6 months. Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6. MAIN OUTCOME MEASURE(S): Primary: sperm concentration, motility, morphology, and DNA fragmentation at baseline. Secondary: cumulative pregnancy, miscarriage, and live birth rates. RESULT(S): Semen parameters and sperm DNA fragmentation were not statistically significantly different between men with vitamin D deficiency and men with 25(OH)D levels ≥20 ng/mL. In addition, clinical pregnancy and live birth rates were similar. Male 25(OH)D level <20 ng/mL was associated with a higher rate of pregnancy loss (adjusted odds ratio 9.0; 95% confidence interval 1.3 to 61.3). CONCLUSION(S): Vitamin D deficiency in the male partner did not significantly impact semen parameters or treatment outcomes. Further study is warranted to better characterize the rate of miscarriage in couples with male vitamin D deficiency.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.