Evidence map›Paper›PMID 34289887›Full record

ArticleArthritis research & therapy2021

Altered circulating CCR6

Zhonghua Liao, Jiale Tang, Liying Luo, Shuanglinzi Deng, Lisa Luo, Fangyuan Wang, Xiangning Yuan, Xinyue Hu, Juntao Feng, Xiaozhao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhonghua LiaoDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Jiale TangDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Liying LuoDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Shuanglinzi DengDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Lisa LuoDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Fangyuan WangDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiangning YuanDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xinyue HuDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Juntao FengDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiaozhao LiDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. lixiaozhao@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEffector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and are involved in the pathogenesis of ANCA-associated vasculitis (AAV). The diversity of effector memory T cells in chemokine receptor expression has been well studied in proteinase 3 (PR3)-AAV. However, few studies have been conducted in myeloperoxidase (MPO)-AAV. Here, we characterized chemokine receptor expression on effector memory T cells from patients with active MPO-AAV.

methodsClinical data from newly diagnosed MPO-AAV patients and healthy subjects were collected and analyzed. Human peripheral blood mononuclear cells (PBMCs) isolated from patients with active MPO-AAV were analyzed by flow cytometry. The production of effector memory T cell-related chemokines in serum was assessed by ELISA.

resultsWe observed decreased percentages of CD4

conclusionsOur data indicate that dysregulated chemokine receptor expression on CD4

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisT-Lymphocyte SubsetsAntibodies, Antineutrophil CytoplasmicCD8-Positive T-LymphocytesHumansKidneyLeukocytes, MononuclearPeroxidasePrognosisReceptors, CCR6Receptors, CXCR3Antibodies, Antineutrophil CytoplasmicCCR6 protein, humanCXCR3 protein, humanPeroxidaseReceptors, CCR6Receptors, CXCR3Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitisEffector memory T cellsKidney survivalMyeloperoxidase

Identifiers

PMID34289887
PMCPMC8293504
OpenAlexW3183468785

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.