ArticleJournal of biological engineering2021
Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine.
Article in Journal of biological engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Lateral Ridge Augmentation Using Low-dosage Bone Morphogenetic Protein-2 Functionalised Calcium Phosphate Cement.International dental journal · 2026Article
- The efficacy of blood-derived growth factor source compared to bone-derived growth factor source on bone regeneration in critical-sized rabbit calvarial bone defects.BMC oral health · 2026Article
- The efficacy of injectable bone fillers for alveolar ridge preservation: a microcomputed tomographic analysis.International journal of implant dentistry · 2026Article
- Material-dependent effects of injectable platelet rich-fibrin on growth factor release, inflammation, and osteoclast activity: an in vitro study.BMC oral health · 2026Article
- Sticky Bone: Advances and Applications.International journal of nanomedicine · 2025Review
- The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects.Saudi medical journal · 2024Article
- Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization.Frontiers in bioengineering and biotechnology · 2024Review
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Alveolar Ridge Preservation with Autologous Platelet-Rich Fibrin (PRF): Case Reports and the Rationale.Dentistry journal · 2023Review
- Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing.Journal of diabetes research · 2023Article
- The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review ofThe Japanese dental science review · 2022Article
- Utilizing 3D bioprinted platelet-rich fibrin-based materials to promote the regeneration of oral soft tissue.Regenerative biomaterials · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) as the potential candidate for extracted socket healing is introduced. The combination of GNPs and i-PRF not only possesses favorable mechanical properties to withstand external force but also accelerate the blood clotting time significantly. In addition, six beagle dogs were adopted to assess the angiogenic and osteogenic capacity of GNPs+i-PRF gel in vivo. The GNPs+i-PRF gel significantly produced the most blood vessels area, woven bone and low osteoclast activity in extracted sockets at 2 weeks postoperation and remarkably generated corticalization on the alveolar ridge crest at 8 weeks postoperation according to histological results. Therefore, GNPs+i-PRF gel can be recommended as the candidate grafting material regarding ridge preservation for its cost effectiveness, excellent biocompatibility, facilitation of blood clotting and favorable capacity of promoting angiogenesis and osteogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.