Evidence map›Paper›PMID 34289855›Full record

ArticleOrphanet journal of rare diseases2021

Clinical features and treatment efficacy for IgG4-related thyroiditis.

Xinxin Han, Panpan Zhang, Jieqiong Li, Zheng Liu, Hui Lu, Xuan Luo, Boju Pan, Xiaolan Lian, Xuejun Zeng, Wen Zhang and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xinxin Han *Department of General Practice, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, People's Republic of China.
Panpan Zhang *Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Jieqiong LiDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Zheng LiuDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Hui LuDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Xuan LuoDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Boju PanDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, People's Republic of China.
Xiaolan LianDepartment of Endocrine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, People's Republic of China.
Xuejun ZengDepartment of General Practice, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, People's Republic of China. zxjpumch@126.com.ORCID http://orcid.org/0000-0002-6426-7586
Wen ZhangDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China. zhangwen91@sina.com.ORCID http://orcid.org/0000-0001-7808-9867
Xiaofeng ZengDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to clarify the clinical features of and evaluate the treatment efficacy for IgG4-related thyroiditis.

methodsFourteen IgG4-related thyroiditis patients and 42 randomly matched IgG4-related disease (IgG4-RD) patients without thyroiditis in a prospective cohort at the Peking Union Medical College Hospital (PUMCH) were enrolled from 2011 to 2019. Patient demographics, clinical characteristics, laboratory parameters and treatment efficacy were analysed.

resultsThe prevalence of IgG4-related thyroiditis in our cohort was 2.0%. The average patient age was 42.8 ± 14.9 years, and the male: female ratio was 1:1. Goiter (14, 100.0%), hard thyroid (14, 100.0%) and neck compression (5, 35.7%) were the most prevalent onset symptoms observed. IgG4-related thyroiditis was characterized by asymmetric diffuse thyroid enlargement on ultrasound. Thirteen (92.9%) patients had hypothyroidism, and all patients had significantly elevated circulating thyroid antibodies. Compared with patients without thyroiditis, patients with IgG4-related thyroiditis had less submandibular gland involvement and lacrimal gland involvement and lower serum IgG4 and T-IgE levels (P = 0.019, P = 0.022, P = 0.004, and P = 0.006, respectively) and more single-organ involvement (P = 0.011). After treatment, the symptoms were relieved, while the size of the thyroid gland did not change significantly, and levothyroxine as a supplemental therapy was still needed.

conclusionsIgG4-related thyroiditis is a distinct subtype of IgG4-RD characterized by positive circulating thyroid antibodies and a high rate of hypothyroidism. Although compression symptoms could be relieved with treatment, the thyroid size did not change significantly, and the damage to thyroid function was often irreversible.

Indexed as

Immunoglobulin G4-Related DiseaseThyroiditisAdultFemaleHumansImmunoglobulin GMaleMiddle AgedProspective StudiesTreatment OutcomeImmunoglobulin G

Identifiers

PMID34289855
PMCPMC8293477
OpenAlexW3184070051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.