Evidence map›Paper›PMID 34289754›Full record

ReviewDrug metabolism reviews2021

Rodent genetic models of Ah receptor signaling.

Rachel H Wilson, Christopher A Bradfield

Open access · greenAbstract readReview
In one paragraph

Review in Drug metabolism reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Loss ofFrontiers in immunology · 2024
    Article
  7. Article
  8. Phenobarbital in Nuclear Receptor Activation: An Update.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel H WilsonMolecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA.
Christopher A BradfieldMolecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
The PAS Sensor Family and Human HealthR35ES028377 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI BRADFIELD, CHRISTOPHER A · 2017 to 2024
$6.7M
NCI NIH HHS P30 CA014520NIEHS NIH HHS R35 ES028377NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has been a molecule of interest for many years in the field of toxicology, as it was originally discovered to mediate the toxic effects of certain environmental pollutants like benzo(

Indexed as

Aryl Hydrocarbon Receptor Nuclear TranslocatorPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonAnimalsHumansMiceModels, AnimalRatsAryl Hydrocarbon Receptor Nuclear TranslocatorPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonAHRARA9ARNTaryl hydrocarbon receptorgene editingmouse modelrat model

Identifiers

PMID34289754
PMCPMC9059429
OpenAlexW3183403095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.