ArticleEndocrine connections2021
The association between expression of lncRNAs in patients with GDM.
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The value of lncRNAs as a biomarker for the pregnancy outcomes of gestational diabetes: a meta-analysis.Irish journal of medical science · 2025Pooled it
- Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study.Nutrition journal · 2025Article
- Non-coding RNAs: the architects of placental development and pregnancy success.Molecular genetics and genomics : MGG · 2025Review
- LncRNAs Involved in Antioxidant Response Regulation as Biomarkers of Gestational Diabetes: A Study onAntioxidants (Basel, Switzerland) · 2024Article
- Long noncoding RNAs and metabolic memory associated with continued progression of diabetic retinopathy.Journal of diabetes · 2024Article
- Value of Non-Coding RNA Expression in Biofluids to Identify Patients at Low Risk of Pathologies Associated with Pregnancy.Diagnostics (Basel, Switzerland) · 2024Review
- The role of ncRNA regulatory mechanisms in diseases-case on gestational diabetes.Briefings in bioinformatics · 2023Review
- Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers.World journal of diabetes · 2023Article
- Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes.International journal of molecular sciences · 2023Review
- Circulating lncRNAs NONHSAT054669.2 and ENST00000525337 can be used as early biomarkers of gestational diabetes mellitus.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy.Frontiers in endocrinology · 2023Review
- The Mystery of Exosomes in Gestational Diabetes Mellitus.Oxidative medicine and cellular longevity · 2022Review
- Effects of Early Nursing Monitoring on Pregnancy Outcomes of Pregnant Women with Gestational Diabetes Mellitus under Internet of Things.Computational and mathematical methods in medicine · 2022Article
- Upregulation of T Cell Receptor Signaling Pathway Components in Gestational Diabetes Mellitus Patients: Joint Analysis of mRNA and circRNA Expression Profiles.Frontiers in endocrinology · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGestational diabetes mellitus (GDM) is common worldwide and seriously threatens maternal and infant health. The expression of non-coding (ncRNA) is tissue-specific and highly stable in eukaryotic cells and the circulatory system, which can act as an early molecular marker of GDM.
methodsThe differential expression of lncRNA and mRNA in the peripheral blood of patients with GDM (experimental group) and healthy pregnant women (control group) was analysed via lncRNA gene chip. Employing biological function clustering and KEGG signalling pathway analysis, we selected the mRNAs and lncRNAs closely related to the insulin signalling pathway of GDM to analyse the possible regulatory mechanism in the pathogenesis of GDM. The sequencing results were further verified via quantitative PCR (Q-PCR).
resultsLncRNA microarray analysis revealed 7498 genes (3592 upregulated, 3906 downregulated) differentially expressed in the GDM group and healthy pregnant women control group, including 1098 differentially expressed lncRNAs (609 upregulated, 489 downregulated). According to the regulatory pathway of the lncRNA mRNA network, 6 lncRNAs and 4 mRNAs were found to play a significant role in insulin resistance.
conclusionsThe lncRNAs ERMP1, TSPAN32 and MRPL38 form a co-expression network with TPH1, which is mainly involved in the tryptophan metabolism pathway and in the development of GDM. Moreover, lncRNA RPL13P5 forms a co-expression network with the TSC2 gene via the PI3K-AKT and insulin signalling pathways, which are involved in the process of insulin resistance in GDM.
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