ArticleCell host & microbe2021
Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice.
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Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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38 citing papers in PubMed, 53 citations in OpenAlex.
- Dietary and nutritional strategies for reducing disease risk associated with antibiotic-induced dysbiosis.Gut microbes · 2026Review
- Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.Nature communications · 2026Article
- The Role of Microbiota in Type 1 Diabetes: Insights into Dysbiosis and Immune Interactions.Nutrients · 2026Review
- [Gut microbiota dysbiosis in type 1 diabetes mellitus: Impacts, mechanisms, and interventions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Inhibition of PFKFB3 in macrophages ameliorates intestinal inflammation by modulating gut microbiota in DSS-induced colitis.mSystems · 2026Article
- Endotoxin Tolerance Impinges on T Cell Activation and Chemoattraction in Autoimmune Diabetes.Journal of immunology research · 2026Article
- Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment.Research square · 2025Article
- Unraveling Type 1 Diabetes: Integrating Microbiome, Metabolomics, and Immunomodulation for Next-Generation Therapies.International journal of molecular sciences · 2025Review
- Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development.Science (New York, N.Y.) · 2025Article
- Antibiotic-perturbed microbiota and the role of probiotics.Nature reviews. Gastroenterology & hepatology · 2025Review
- Gut Microbiota-Derived Hyocholic Acid Enhances Type 3 Immunity and Protects Against Salmonella enterica Serovar Typhimurium in Neonatal Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases.Foods (Basel, Switzerland) · 2025Review
- Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice.Science China. Life sciences · 2025Article
- Critical assessment of nanopore sequencing for the detection of multiple forms of DNA modifications.bioRxiv : the preprint server for biology · 2024Article
- Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome.The Journal of infectious diseases · 2024Review
- Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy.bioRxiv : the preprint server for biology · 2024Article
- The Microbiome and Infectious Diseases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Gut Microbiota Is Associated with Onset and Severity of Type 1 Diabetes in Nonobese Diabetic Mice Treated with Anti-PD-1.ImmunoHorizons · 2023Article
- Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging.iScience · 2023Article
- The microbiota of pregnant women with SARS-CoV-2 and their infants.Microbiome · 2023Article
Corrections and comments
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Authors and funding
29 authors at 6 institutions in 3 countries.
Xue-Song ZhangCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA. Electronic address: xuesong.zhang@rutgers.edu.
Yue Sandra YinCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Jincheng WangDepartment of Biochemistry and Microbiology, Rutgers University - New Brunswick, New Brunswick, NJ, USA.
Thomas BattagliaHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Kimberly KrautkramerThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg 41345, Sweden.
Wei Vivian LiDepartment of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, NJ, USA.
Jackie LiHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Mark BrownCardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
Meifan ZhangCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Michelle H BadriHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA; New York University, Center for Data Science, New York, NY, USA.
Abigail J S ArmstrongCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
Christopher M StrauchCardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
Zeneng WangCardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
Ina NemetCardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
Nicole AltomareCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
Joseph C DevlinHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Linchen HeDepartment of Population Health, New York University Langone Medical Center, New York, NY, USA.
Jamie T MortonHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
John Alex ChalkCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
Kelly NeedlesCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
Viviane LiaoCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
Julia MountHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Huilin LiDepartment of Population Health, New York University Langone Medical Center, New York, NY, USA.
Kelly V RugglesHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
Richard A BonneauHuman Microbiome Program, New York University Langone Medical Center, New York, NY, USA; New York University, Center for Data Science, New York, NY, USA; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
Maria Gloria Dominguez-BelloDepartment of Biochemistry and Microbiology, Rutgers University - New Brunswick, New Brunswick, NJ, USA; Institute for Food, Nutrition and Health, Rutgers University - New Brunswick, New Brunswick, NJ, USA.
Fredrik BäckhedThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg 41345, Sweden; Region västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stanley L HazenCardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44195, USA; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Martin J BlaserCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA. Electronic address: martin.blaser@cabm.rutgers.edu.
Rutgers, The State University of New Jersey · USNYU Langone Health · USCleveland Clinic Lerner College of Medicine · USNew York University · USUniversity of Gothenburg · SESimons Foundation · US
Funding
Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MICHAEL ANDREW FISCHBACH · 2019 to 2026
$17.0MHigh Resolution Characterization of Bacterial Epigenomes and MicrobiomeR35GM139655 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Gang Fang · 2021 to 2026
$4.9MHigh Resolution Characterization of Gut Microbiome and its Response to AntibioticsR01GM128955 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FANG, GANG · 2018 to 2020
$1.9MThe Role of Bacterial Choline Metabolism in Host Stress ResponsesR01DK120679 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK · 2019 to 2022
$1.6MNovel Statistical Methods in Analyzing Microbiome Data for Longitudinal StudyR01DK110014 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LI, HUILIN · 2016 to 2019
$1.5MNHLBI NIH HHS P01 HL147823NIDDK NIH HHS R01 DK110014NIDDK NIH HHS R01 DK120679NIGMS NIH HHS R01 GM128955NIGMS NIH HHS R35 GM139655
Abstract
Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury.
Indexed as
AnimalsAnti-Bacterial AgentsAutoimmune DiseasesBacteriaCecumDiabetes Mellitus, Type 1Disease Models, AnimalFemaleGastrointestinal MicrobiomeGene ExpressionHistone CodeIntestinesMaleMetabolic Networks and PathwaysMetagenomeMiceAnti-Bacterial AgentsMicroRNAsanimal modelsautoimmunececal material transfergene expressionhistone modificationinnate immunemicrobiomemicroRNANOD micetype 1 diabetes
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