ArticleCell reports2021
The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Proteome Remodelling inJournal of fungi (Basel, Switzerland) · 2026Article
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- Long-read microbial genome assembly, gene prediction and functional annotation: a service of the MIRRI ERIC Italian node.Frontiers in bioinformatics · 2025Article
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- Loss of the accessory chromosome converts a pathogenic tree-root fungus into a mutualistic endophyte.Plant communications · 2024Article
- Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused byFrontiers in microbiology · 2022Article
- Article
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Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
Abstract
Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to chromatin architecture. Here, we report a pivotal role for the HIR histone chaperone complex in modulating virulence of the human fungal pathogen Candida albicans. Genetic ablation of HIR function alters chromatin accessibility linked to aberrant transcriptional responses to protein as nitrogen source. This accelerates metabolic adaptation and increases the release of extracellular proteases, which enables scavenging of alternative nitrogen sources. Furthermore, HIR controls fungal virulence, as HIR1 deletion leads to differential recognition by immune cells and hypervirulence in a mouse model of systemic infection. This work provides mechanistic insights into chromatin-coupled regulatory mechanisms that fine-tune pathogen gene expression and virulence. Furthermore, the data point toward the requirement of refined screening approaches to exploit chromatin modifications as antifungal strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.