ArticleAmerican heart journal2021
Coarctation of aorta is associated with left ventricular stiffness, left atrial dysfunction and pulmonary hypertension.
Article in American heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- Prognostic value of right ventricular-pulmonary arterial coupling in adults with repaired coarctation of aorta.International journal of cardiology. Congenital heart disease · 2025Article
- Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta.International journal of cardiology. Heart & vasculature · 2025Article
- Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta.Circulation. Heart failure · 2025Article
- Analysis of the Independent Risk Factors of second-Degree Atrioventricular Block in Patients with Atrial Fibrillation and the Diagnostic Efficacy of Dynamic Electrocardiogram.International journal of general medicine · 2025Article
- Incidence, Correlates, and Prognostic Implications of New-Onset Atrial Fibrillation in Adults With Repaired Coarctation of Aorta.CJC pediatric and congenital heart disease · 2024Article
- Sex Differences in Outcomes of Adults with Repaired Coarctation of Aorta and Concomitant Aortic Valve Disease.CJC open · 2024Article
- Impact of Obesity on Ventriculo-Arterial Interaction in Patients After Coarctation of Aorta repair.Pediatric cardiology · 2024Article
- Pulmonary vascular disease, environmental pollution, and climate change.Pulmonary circulation · 2024Review
- Determinants and prognostic implications of left atrial reverse remodelling after coarctation of aorta repair in adults.European heart journal. Cardiovascular Imaging · 2024Article
- Prognostic Value of the Anatomic-Physiologic Classification in Adults With Congenital Heart Disease.Circulation. Heart failure · 2023Article
- Prognostic Role of Tricuspid Annular Plane Systolic Excursion/Right Ventricular Systolic Pressure Ratio in Coarctation of Aorta.CJC pediatric and congenital heart disease · 2023Article
- Using computed tomography angiography and computational fluid dynamics to study aortic coarctation in different arch morphologies.Frontiers in pediatrics · 2023Article
- Prognostic Value of the HJACC. Advances · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundBrachial systolic blood pressure (BP) is the most commonly used metric for monitoring hypertension. However, recent studies suggest that brachial systolic BP underestimates left ventricle (LV) systolic load in patients with coarctation of aorta (COA). Since brachial systolic BP is used as a surrogate of arterial afterload in clinical practice, it is important to determine how well it correlates with LV remodeling and stiffness in patients with COA as compared to patients with idiopathic hypertension.
methodsThis is cross-sectional study of COA patients with hypertension (COA group) and adults with idiopathic hypertension (control group). Both groups were matched 1:1 based on age, sex, BMI and systolic BP. We hypothesized that the COA group will have higher LV systolic and diastolic stiffness, and more advanced left atrial remodeling and pulmonary hypertension. We assessed LV systolic stiffness using end-systolic elastance, and diastolic stiffness using LV stiffness constant and chamber capacitance (LV-end-diastolic volume at an end-diastolic pressure of 20mm Hg)
resultsThere were 112 patients in each group. Although both groups had similar systolic BP, the COA group had a higher end-systolic elastance (2.37 ± 0.74 vs 2.11 ± 0.54 mm Hg/mL, P= .008), higher LV stiffness constant (6.91 ± 0.81 vs 5.93 ± 0.79, P= .006) and lower LV-end-diastolic volume at an end-diastolic pressure of 20mm Hg (58 ± 9 vs 67 ± 11 mL/m
conclusionsCOA patients have more LV stiffness and abnormal hemodynamics compared to non-COA patients with similar systolic BP, suggesting that systolic BP may underestimate LV systolic load in this population. Further studies are required to determine whether the observed LV stiffness and dysfunction translates to more cardiovascular events during follow-up, and whether adopting a stricter systolic BP target in clinical practice or changing threshold for COA intervention will lead to less LV stiffness and better clinical outcomes.
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