Evidence map›Paper›PMID 34289148›Full record

ArticleJournal of medical virology2021

Seroprevalence of SARS-CoV-2 antibodies among rural healthcare workers.

Jordan Z Neises, Md Saddam Hossain, Rifat Sultana, Kevin N Wanniarachchi, Jared W Wollman, Eric Nelson, Bonny L Specker, Adam D Hoppe, Steven R Lawson, Natalie W Thiex

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jordan Z NeisesDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Md Saddam HossainDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota, USA.
Rifat SultanaDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Kevin N WanniarachchiDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Jared W WollmanDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Eric NelsonDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Bonny L SpeckerEA Martin Program in Human Nutrition, South Dakota State University, Brookings, South Dakota, USA.
Adam D HoppeDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota, USA.
Steven R LawsonDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Natalie W ThiexDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.ORCID 0000-0001-7028-094X
South Dakota State University · US

Funding

BioSNTRSouth Dakota Agriculture Experiment StationSouth Dakota Governors Office of Economic Development
6 · The paper itself

Abstract

The objective of this longitudinal cohort study was to determine the seroprevalence of antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in healthcare workers employed at healthcare settings in three rural counties in eastern South Dakota and western Minnesota from May 13, 2020, through December 22, 2020. Three blood draws were performed at five clinical sites and tested for the presence of antibodies against the SARS-CoV-2. Serum samples were tested for the presence of antibodies using a fluorescent microsphere immunoassay (FMIA), neutralization of SARS-CoV-2 spike-pseudotyped particles (SARS-CoV-2pp) assay, and serum virus neutralization (SVN) assay. The seroprevalence was determined to be 1/336 (0.29%) for samples collected from 5/13/20 to 7/13/20, 5/260 (1.92%) for samples collected from 8/13/20 to 9/25/20, and 35/235 (14.89%) for samples collected from 10/16/20 to 12/22/20. Eight of the 35 (22.8%) seropositive individuals identified in the final draw did not report a previous diagnosis with COVID-19. There was a high correlation (>90%) between the FMIA and virus neutralization assays. Each clinical site's seroprevalence was higher than the cumulative incidence for the general public in the respective county as reported by state public health agencies. As of December 2020, there was a high percentage (85%) of seronegative individuals in the study population.

Indexed as

AdolescentAdultAntibodies, NeutralizingAntibodies, ViralCOVID-19FemaleFluorescent Antibody TechniqueHealth PersonnelHumansMaleMiddle AgedMinnesotaNeutralization TestsRural Health ServicesSARS-CoV-2Seroepidemiologic StudiesAntibodies, NeutralizingAntibodies, ViralCOVID-19healthcare workerruralSARS-CoV-2seroprevalence

Identifiers

PMID34289148
PMCPMC8426917
OpenAlexW3186650590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.