Evidence map›Paper›PMID 34289049›Full record

ReviewJournal of molecular cell biology2021

Epigenetic regulation of energy metabolism in obesity.

Wei Gao, Jia-Li Liu, Xiang Lu, Qin Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei GaoDepartment of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0002-4770-5062
Jia-Li LiuDepartment of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China.
Xiang LuDepartment of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China.
Qin YangDepartment of Medicine, Physiology and Biophysics, UC Irvine Diabetes Center, University of California Irvine, Irvine, CA 92697, USA.

Funding

Epigenetic Regulation of Mitochondrial Homeostasis and Energy MetabolismR01DK121146 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI Qin Yang · 2019 to 2026
$3.5M
NIDDK NIH HHS R01 DK121146
6 · The paper itself

Abstract

Obesity has reached epidemic proportions globally. Although modern adoption of a sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause of obesity epidemic, genetic preposition contributes significantly to the imbalanced energy metabolism in obesity. However, the variants of genetic loci identified from large-scale genetic studies do not appear to fully explain the rapid increase in obesity epidemic in the last four to five decades. Recent advancements of next-generation sequencing technologies and studies of tissue-specific effects of epigenetic factors in metabolic organs have significantly advanced our understanding of epigenetic regulation of energy metabolism in obesity. The epigenome, including DNA methylation, histone modifications, and RNA-mediated processes, is characterized as mitotically or meiotically heritable changes in gene function without alteration of DNA sequence. Importantly, epigenetic modifications are reversible. Therefore, comprehensively understanding the landscape of epigenetic regulation of energy metabolism could unravel novel molecular targets for obesity treatment. In this review, we summarize the current knowledge on the roles of DNA methylation, histone modifications such as methylation and acetylation, and RNA-mediated processes in regulating energy metabolism. We also discuss the effects of lifestyle modifications and therapeutic agents on epigenetic regulation of energy metabolism in obesity.

Indexed as

EpidemicsEpigenesis, GeneticAcetylationAnimalsDNA MethylationEnergy MetabolismHistone CodeHistonesHumansLife StyleMolecular Targeted TherapyObesityRNAHistonesRNAenergy metabolismepigeneticsobesitytreatment

Identifiers

PMID34289049
PMCPMC8530523

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.