Evidence map›Paper›PMID 34289037›Full record

ReviewJournal of molecular cell biology2021

Emerging neurotropic features of SARS-CoV-2.

Wen-Rong Zhan, Jing Huang, Peng-Ming Zeng, Wei-Ya Tian, Zhen-Ge Luo

Open access · goldAbstract readReview
In one paragraph

Review in Journal of molecular cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Autoimmune myasthenia gravis and COVID-19. A case report-based review.The Journal of international medical research · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Effects of COVID-19 on children with autism.World journal of virology · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen-Rong ZhanSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Jing HuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Peng-Ming ZengSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wei-Ya TianSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhen-Ge LuoSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.ORCID 0000-0001-5037-0542
ShanghaiTech University · CN

Funding

Frontier Key Project of the Chinese Academy of Sciences QYZDJ-SSW-SMC025National Key R&D Program of China 2017YFA0700500Shanghai Municipal Science and Technology Projects 2018SHZDZX05
6 · The paper itself

Abstract

The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain-Barre syndrome, and some neuropsychiatric disorders. Although several cell types in the brain express angiotensin-converting enzyme-2 (ACE2), the main SARS-CoV-2 receptor, and other related proteins, it remains unclear whether the observed neurological manifestations are attributed to virus invasion into the brain or just comorbidities caused by dysregulation of systemic factors. Here, we briefly review the neurological manifestations of SARS-CoV-2, summarize recent evidence for the potential neurotropism of SARS-CoV-2, and discuss the potential mechanisms of COVID-19-associated neurological diseases.

Indexed as

BrainCOVID-19HumansNervous System DiseasesSARS-CoV-2ACE2brain invasionneurological manifestationsSARS-CoV-2

Identifiers

PMID34289037
PMCPMC8344859
OpenAlexW3184636534

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.