Evidence map›Paper›PMID 34288736›Full record

ArticleMolecular biology of the cell2021

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.

Marbelys Rodriguez Pino, Illyce Nuñez, Chuan Chen, Maitreyi E Das, David J Wiley, Gennaro D'Urso, Peter Buchwald, Dimitrios Vavylonis, Fulvia Verde

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marbelys Rodriguez PinoDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Illyce NuñezDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Chuan ChenDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Maitreyi E DasDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
David J WileyDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Gennaro D'UrsoDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Peter BuchwaldDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
Dimitrios VavylonisDepartment of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA, 18015.
Fulvia VerdeDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015.
University of Miami · USLehigh University · US

Funding

Modeling mechanisms in cytokinesis, cell polarization and motilityR35GM136372 · NIGMS · LEHIGH UNIVERSITY · PI Dimitrios Vavylonis · 2020 to 2026
$3.2M
Control of cell morphogenesis and cell growth by conserved NDR kinase Orb6R01GM129514 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VERDE, FULVIA · 2019 to 2022
$1.2M
Theoretical and experimental studies of distributed actin turnoverR01GM114201 · NIGMS · LEHIGH UNIVERSITY · PI VAVYLONIS, DIMITRIOS · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM114201NIGMS NIH HHS R01 GM129514NIGMS NIH HHS R35 GM136372
6 · The paper itself

Abstract

The highly conserved small GTPase Cdc42 regulates polarized cell growth and morphogenesis from yeast to humans. We previously reported that Cdc42 activation exhibits oscillatory dynamics at cell tips of

Indexed as

cdc42 GTP-Binding ProteinCell Cycle ProteinsCell PolarityGenome, FungalGenome-Wide Association StudyGTPase-Activating ProteinsMutationSchizosaccharomycesSchizosaccharomyces pombe Proteinscdc42 GTP-Binding Proteincdc42 protein, S pombeCell Cycle ProteinsGTPase-Activating ProteinsRga4 protein, S pombescd2 protein, S pombeSchizosaccharomyces pombe Proteins

Identifiers

PMID34288736
PMCPMC8684747
OpenAlexW3186531808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.